• Mechanisms of cellular membrane remodeling
• Membrane Nanomechanics

Anna Shnyrova

Ramon y Cajal Fellow

• PhD in Chemistry from the University of Salamanca (Spain)
• Previous research experience at the National Institutes of Health (USA)
Research line: Mechanisms of cellular membrane remodeling

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Publications

• Nonlinear material and ionic transport through membrane nanotubes

  D. V Ivchenkov, P. I. Kuzmin, T. R. Galimzyanov, A. V Shnyrova, P. V Bashkirov, V. A. Frolov

  Biochim. Biophys. Acta - Biomembr. 2021, 1863, DOI 10.1016/j.bbamem.2021.183677 (2021)

• Microfluidic chip with pillar arrays for controlled production and observation of lipid membrane nanotubes

  Martinez Galvez JM, Garcia-Hernando M, Benito-Lopez F, Basabe-Desmonts L, Shnyrova AV.

  Lab Chip. 20(15):2748-2755. (2020) doi: 10.1039/d0lc00451k (2020)

• Reconstitution and real-time quantification of membrane remodeling by single proteins and protein complexes

  Bashkirov PV, Kuzmin PI, Chekashkina K, Arrasate P, Vera Lillo J, Shnyrova AV, Frolov VA.

  Nat Protoc. 15(8):2443-2469. (2020) doi: 10.1038/s41596-020-0337-1. (2020)

• Electrophysiological Methods for Detection of Membrane Leakage and Hemifission by Dynamin 1

  Bashkirov PV, Chekashkina KV, Shnyrova AV, Frolov VA.

  Methods Mol Biol. 2159:141-162 (2020). doi: 10.1007/978-1-0716-0676-6_11. (2020)

• Dynamic constriction and fission of endoplasmic reticulum membranes by reticulon

  Espadas J, Pendin D, Bocanegra R, Escalada A, Misticoni G, Trevisan T, Velasco Del Olmo A, Montagna A, Bova S, Ibarra B, Kuzmin PI, Bashkirov PV, Shnyrova AV, Frolov VA, Daga A.

  Nat Commun. 10(1):5327 (2019). doi: 10.1038/s41467-019-13327-7. (2019)

• Combining patch-clamping and fluorescence microscopy for quantitative reconstitution of cellular membrane processes with Giant Suspended Bilayers

  Velasco-Olmo A, Ormaetxea Gisasola J, Martinez Galvez JM, Vera Lillo J, Shnyrova AV

  Sci Rep. 9(1):7255. doi: 10.1038/s41598-019-43561-4. (2019)

• Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge

  J.H. Hervas, A. Landajuela, Z. Anton, A.V. Shnyrova, F.M. Goni and A. Alonso

  Sci Rep 7, 15614 doi: 10.1038/s41598-017-15057-6 (2017)

• Dynamin-catalyzed membrane fission occurs in two mechanistically distinct stages

  Juha-Pekka Mattila*, Anna V. Shnyrova*, Anna S Sundborger, Eva Rodriguez Hortelano, Mark Fuhrmans, Sylvia Neumann, Marcus Müller, Jenny E Hinshaw, Sandra L Schmid, Vadim A Frolov , (* These authors contributed equally) ,

  Nature 524, pp. 109-113. (2015)

• Geometry of membrane fission

  V.A. Frolov, A. Escalada, S.A. Akimov and A. Shnyrova.

  Chem Phys Lipids. 185, 129-140 (2015)

• Stochastic transport through carbon nanotubes in lipid bilayers and live cell membranes.

  J. Geng, K. Kim, J. Zhang, A. Escalada, R. Tunuguntla, L.R. Comolli, F.I. Allen, A.V. Shnyrova, K.R. Cho, D. Muñoz, Y.M. Wang, C. P. Grigoropoulos, C.M. Ajo-Franklin, V.A. Frolov and A. Noy.

  Nature 514, 612-615 (2014).

• Geometric catalysis of membrane fission driven by flexible dynamin rings.

  A.V. Shnyrova, P.V. Bashkirov, S.A. Akimov, T.J. Pucadyil, J. Zimmerberg, S.L. Schmid and V.A. Frolov.

  Science 339, 1433-1436 (2013).

• Lipid polymorphisms and membrane shape.

  Vadim A. Frolov, Anna V. Shnyrova, Joshua Zimmerberg

  Cold Spring Harb Perspect Biol ;3:a004747 (2011).