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The Membrane Trafficking Lab, led by Dr. Aitor Hierro at Instituto Biofisika (University of the Basque Country, Leioa, Spain), is offering a full-time four-year Ph.D. position in structural biology, supported by The Spanish Ministry of Science, Innovation, and Universities. The contract will be part of the grant PID2023-151986NB-I00, funded by MCIU/AEI/10.13039/501100011033 and funded by the FSE+.

Starting in December 2024/February 2025, we offer a (4-year) predoctoral position at the Theoretical Biophysics Lab, under the supervision of Dr. Daniele De Martino and Prof. Kepa Ruiz Mirazo.
The investigation to be carried out will involve the development of a theoretical framework, taking as a basis the theory of phase transitions in Statistical Physics, to explain complex emergent phenomena in diverse biological cells. More specifically, it will focus on intercellular metabolic exchange networks, including their experimental validation in cancer metabolism and microbial overflow. We are searching for candidates with a solid scientific background, good attitude for team-work, open-minded for interdisciplinary research, strong theoretical/computational skills and motivation to apply them to the life sciences.

We offer a predoctoral position at the Membrane Transport Mechanisms lab (https://www.biofisika.org/en/research/membrane-transport-mechanisms) at Instituto Biofisika (Leioa) under the supervision of Dr. Igor Tascón.
This is a full-time, four-year position funded by The Spanish Ministry of Science, Innovation and Universities. The contract will be part of the grant PID2023-146771NB-I00, funded by MCIU/AEI/10.13039/501100011033 and funded by the FSE+.

A predoctoral position in Structural Biology is available in the Membrane Trafficking Laboratory lead by Dr. Aitor Hierro within the Instituto Biofisika (https://www.biofisika.org/en/research/membrane-trafficking) at the University of the Basque Country in Leioa, Spain. This is a full-time, four-year position funded by The Spanish Ministry of Science, Innovation and Universities. The contract will be part of the grant PID2023-151986NB-I00, funded by MCIU/AEI/10.13039/501100011033 and funded by the FSE+.

We offer a University Graduate position at the Numerical Methods for Cryo Electron Tomography lab at Instituto Biofisika (Leioa) under the supervision of Dr. Daniel Castaño.

The research will focus on meta-learning for the automated analysis of high-resolution cryo-electron tomography images. The researcher needs to have a strong background in Computer Vision.

The offered position is part of the CSIC Momentum program, and the maximum duration of the contract will be until December 2028.

We offer a technician position at the Structural Biology of Genomic Macromolecular Complexes lab at Instituto Biofisika (Leioa) under the supervision of Dr. Guillermo Abascal Palacios.

The ideal candidate must hold an official Degree in Biology, Biochemistry, Biotechnology or similar, and be in possession of a Master in related subjects

This contract is supported by CNS2023-144408 funded by MICIU/AEI /10.13039/501100011033 and by the “European Union NextGenerationEU/PRTR”.

We offer a technician position at the FluoroNanoTools lab at Instituto Biofisika (Leioa) under the supervision of Dr. Mónica Carril. 
The research will focus on the scale up of bioorthogonal strategies to label membrane receptors in vivo. The technician will reproduce and scale up the synthesis of molecules of certain complexity in the frame of a collaborative interdisciplinary project that aims to neuromodulate the neuronal response. We aim to use ligand directed receptor covalent labelling, followed by bioorthogonal binding with suitably modified probes. The researcher needs to have a strong background in organic synthesis and previous experience in handling HPLC-MS equipment will be highly valued.

We offer a postdoctoral position at the FluoroNanoTools lab at Instituto Biofisika (Leioa) under the supervision of Dr. Mónica Carril. 
The research will focus on the development of bioorthogonal strategies to label membrane receptors in vivo. We aim to use ligand directed receptor covalent labelling, followed by biorthoogonal binding with suitably modified probes. Target receptors will be located at the neural membrane and could be AMPAR or TRP type, among others. We look for the combination of different strategies particularly those based on SuFEx reactions and those based on the reaction of tetrazines with trans-cyclooctene. The researcher will have to develop novel molecules to achieve the successful receptor labelling and the bioorthogonal binding with the selected probe, hence a deep knowledge of organic chemistry and/or medicinal chemistry is required. Background in bioorthogonal reactions will also be valued. The research is part of a collaborative interdisciplinary project that aims to neuromodulate the neuronal response.

We have an immediately available predoctoral position in the laboratory of Dr. Jerome Solon, within the Spanish Ministry Programme “Ayudas para contratos predoctorales para la formación de doctores/as”. The position is funded for the complete PhD Thesis, for 4 years.

The position would involve combination of experimental work and analysis to unravel the mechanism of tissue remodeling during Drosophila embryo development. Particularly, we will aim at deciphering the connection between tissue remodeling and nuclear mechanics during morphogenesis. This work will be performed in the Jerome Solon’s laboratory at the Biofisika Institute.

We have an immediately available predoctoral position in the laboratory of Dr. Guillermo Abascal-Palacios at Instituto Biofisika - Basque Centre for Biophysics (CSIC-UPV/EHU).

We are looking for highly motivated candidates interested in pursuing a doctoral thesis in the study of genome-interacting complexes through state-of-the-art structural biology tools. The position is initially funded for 20 months, and the candidates are expected to apply for competitive PhD fellowship applications.

We are looking for highly-motivated candidates to apply for PhD fellowships to pursue a doctoral thesis in the group of Dr. Dmitry Sinelshchikov at Instituto Biofisika (CSIC-UPV/EHU).

The research will focus on the development novel mathematical models in biophysics and methods for their investigation. Possible specific topics include but not limited to mathematical modelling of cavitation processes with applications to biomedicine, mathematical modelling of wound healing and mathematical modeling of neural systems. There is also an opportunity to develop and apply analytical and numerical methods for studying dynamical systems.

We offer a fully funded 4 year Ph.D position (FPI) at the Cell and Tissue Mechanobiology lab at Biofisika Institute (Bilbao) under the supervision of Ion Andreu. 
The research will focus on understanding the role of karyopherins in nuclear mechanotransuction during breast cancer invasion in vitro.  Mechanical forces transmitted through the extracellular matrix or by neighbor cells maintain homeostasis in tissues. Deviation from mechanical homeostasis has long been associated with disease progressions, such as liver fibrosis, atherosclerosis, and cancer. It is well stablished that tissue stiffening promotes the malignant phenotype, and that mechanical activation of cell promotes invasion in breast cancer. At the molecular level, among other effects, mechanical forces control the localization of key cancer transcription regulators and regulate gene expression in breast cancer. However, we are only starting to understand the complexity of mechano-molecular regulation. 
Building up from our previous research, this project aims to unravel force-driven molecular regulation in breast cancer invasion. For that, we will combine molecular biology with biophysical techniques and cutting-edge microscopy. Training on any of these fields will be offered.
 

We invite highly motivated candidates to apply for an immediately available Research Assistant position in the laboratory of Dr. Vadim Frolov at the Basque Centre for Biophysics (IBF; www.biofisika.org) in Leioa, Spain.
The candidate will apply advanced biophysical techniques, such as single molecule fluorescence microscopy, atomic force microscopy and nanopore molecular sensing, to characterize nanomechanical properties and mechano-sensing by synthetic tubular membrane network. The work will be conducted in the membrane nanomechanics group focused on unraveling and exploring fundamental molecular mechanisms of cellular membrane morphogenesis and remodeling, in life and disease.

Immediately available predoctoral position within the research laboratory of Dr. Adai Colom at the Basque Centre for Biophysics (IBF; www.biofisika.org) in Bilbao, Basque Country, Spain.
About the Position: The successful candidate will have the unique opportunity to lead experiments focused on the repair of cell membranes. This research will delve into various repair mechanisms employed by cells when facing different challenges. We will utilize cutting-edge techniques such as Fast-AFM and Confocal Microscopy (www.bralm.cf), Cryo-EM at the Basque Resource for Electron Microscopy (brem.biofisika.org) and Imperial College, to explore and dissect these intricate processes.

Immediately available postdoctoral position in the laboratory within the research laboratory of Dr. Adai Colom at the Basque Centre for Biophysics (IBF; www.biofisika.org) in Bilbao, Basque Country, Spain.
About the Position: The successful candidate will have the unique opportunity to lead experiments focused on the repair of cell membranes. This research will delve into various repair mechanisms employed by cells when facing different challenges. We will utilize cutting-edge techniques such as Fast-AFM and Confocal Microscopy (www.bralm.cf), Cryo-EM at the Basque Resource for Electron Microscopy (brem.biofisika.org) and Imperial College, to explore and dissect these intricate processes.

We invite highly motivated candidates to apply for an immediately available Research Assistant position in the laboratory of Dr. Marité Cárdenas at the Basque Centre for Biophysics (IBF; www.biofisika.org) in Leioa, Spain. We offer a 3-year fixed term contract in the first instance with competitive salary.
The successful candidate will work in the area of neutron scattering and biocolloids. We use a range of biophysical techniques including various microscopies and surface senstitive techniques as support for neutron scattering experiments. We work with a range of recombinant proteins and need to produce them inhouse as well as make use of the lipids in the biomass.

We invite highly motivated candidates to apply for an immediately available two research positions in the laboratory of Dr. David Rodríguez Larrea at the Basque Centre for Biophysics (IBF; www.biofisika.org) in Leioa, Spain.  
The successful candidates will work on developing a next-generation diagnostic tool. It will work by measuring simultaneously many analytes using next-generation single-molecule sensors. We aim to generate molecular barcodes by ligating oligonucleotides of defined sequences. These molecular barcodes can be read one by one with a single-molecule reader (a nanopore). The molecular barcodes will label antibody-like proteins. Following the read of the barcode, the protein is translocated through the nanopore reader and the signal tells whether the antibody had a ligand bound or not.

We invite highly motivated candidates to apply for an immediately available Research Assistant position in the laboratory of Dr. Ion Andreu at the Basque Centre for Biophysics (IBF; www.biofisika.org) in Leioa, Spain.

We offer a 3-year fixed term contract in the first instance with competitive salary.

The successful candidate will work on molecular biology to be applied in 2D and 3D mammalian cell culture.

The key responsibilities will be to generate CRISPR based stable cell lines to tag endogenous proteins, point mutations, deletions. Also, to design and generate molecular tools. And finally, to perform all the molecular biology techniques required in the lab.

Researcher will join the group to study the molecular mechanisms by which the m6A (N6-methyl-adenosine) RNA pathway dynamically fine-tunes gene expression in neurons and its role in cognition. This multidisciplinary project will combine use of molecular and cell biology, animal behavior, advanced biochemistry/proteomics, cytometry assays, and neuroimaging.

Immediately available postdoctoral position in cryo-electron tomography (cryo-ET) in the laboratory of Dr. Iban Ubarretxena-Belandia at the Instituto Biofisika (IBF; //www.biofisika.org/en) in Bilbao, Basque Country (Spain). The laboratory employs cryo-electron microscopy (cryo-EM) to uncover the structure and function of proteins involved in human disease. For recent publications from the laboratory please see: Nature Commun. 2022 13:1050; Nature Commun. 2020 10:2699; Nat Struct Mol Biol. 2020 10:913; and Nat Struct Mol Biol. 2019 26:955.

We seek highly motivated candidates holding a Ph.D. or equivalent in biochemistry, microbiology, structural biology, biophysics, cell biology, biomedical engineering, or related fields. Hands-on experience in cryo-EM and/or cryo-ET will be highly desirable.

A postdoctoral position is available at Instituto Biofisika Basque Centre for Biophysics under the supervision of Prof. Marité Cárdenas (https://biofisika.org). The position is fully funded and has a duration of 2 years.
The open postdoc position will focus on further studying the mechanism of interactions between a bacterial
toxin and cellular membrane. It is expected that the postdoc will be involved additionally in 1 or 2 other
projects run by the group and specially for the PhD students in the group. Surface neutron scattering
techniques will be key to this postdoc position as well as fluorescence microscopy, AFM and single particle CryoEM.

A predoctoral position to do the PhD thesis is available at Instituto Biofisika under the supervision of Prof. Marité Cárdenas Gómez (https://biofisika.org). The position is fully funded and has a duration of 3 years. 
Neutron scattering is a technique that seeks to understand the properties of matter at a structural and dynamic level. Neutron scattering techniques are only available in large facilities, as they can only be produced in nuclear reactors or spallation sources. The European Spallation Source (ESS) is currently being built in Lund, Sweden, and the Basque country has contributed significantly by building key components. 

The "Laboratory for Numerical Methods of Cryo Electron Tomography" is dedicated to advancing computational methods for the automated analysis and interpretation of 3D cell and tissue images. The research project will concentrate on utilizing deep learning techniques to identify and analyze small proteins within their natural surroundings. The laboratory will incorporate cutting-edge image processing methods into their in-house software package Dynamo for cryo electron tomography analysis to achieve this goal.

The IBF is a joint research centre of the University of the Basque Country (UPV/EHU) and the Spanish National Research Council (CSIC). In partnership with Fundación Biofísica Bizkaia (FBB), the centre focuses on advancing knowledge about the physical and chemical processes underlying biology and disease. With the FBB accredited as a Basque Excellence Research Centre (BERC) by the Basque Government, the IBF and FBB partnership enjoys a strong national and international reputation, and provides outstanding shared facilities for advanced biophysical and structural biology approaches in a new research building in the main Leioa campus of the UPV/EHU.

Ideal candidates must hold an official degree in Mathematics, Computer Science, Engineering or similar, and has a strong background in Matlab. An interest in carrying research in Life Sciences is assumed.

A postdoctoral position is available at Instituto Biofisika Basque Centre for Biophysics under the supervision of Prof. Marité Cárdenas (https://biofisika.org) and Prof. Max Wolff (Uppsala University). The position is fully funded and has a duration of 2 years, extendable for another year. This project is part of a Röntgen-Ångström Cluster conducted in collaboration with Uppsala University, Ludwig-Maximilian University and the Jülich center for neutron science.  

Se ofrecen 4 contratos de 2 años a jornada completa de Ayudante de Investigación en el marco del “Programa INVESTIGO” financiado por el Plan de Recuperación, Transformación y Resiliencia de la Unión Europea-NextgenerationEU.

BIOFISIKA es un centro altamente capacitado para llevar a cabo investigación de primer nivel, y está acreditado como Basque Excellence Research Center (BERC) por el Gobierno Vasco.

Las condiciones para participar en el “Programa Investigo” se pueden ver en:
https://www.lanbide.euskadi.eus/general/-/ayuda_subvencion/2021/iker-2022/ 
(Una vez en la página de Lanbide, haced click en “Requisitos de las personas contratadas”)

We are looking for candidates interested in pursuing a doctoral thesis in the laboratory of Dr. Guillermo Abascal-Palacios at Instituto Biofisika Basque Centre for Biophysics (CSIC-UPV/EHU), under a fully-funded FPI contract (4 years) from the Spanish Ministry of Science and Innovation (MICINN).

The "Structural Biology of DNA/RNA-Associated Machineries" laboratory focuses on the study of protein complexes that interact with DNA/RNA, with the aim of determining the molecular mechanisms responsible for their function. To achieve this goal, we carry out a combined process that includes protein complexes cloning and expression techniques, purification using chromatographic tools and their subsequent analysis using biophysical and structural biology methods such as cryo-electron microscopy (Cryo-EM) or X-ray crystallography. The ultimate goal is to determine a high-resolution molecular structure that shows enzymatic activity at the atomic level and that can contribute to the development of drugs against diseases such as colorectal cancer or certain neurological disorders.

We seek highly qualified applicants with experience in single-particle cryo-EM data processing and 3D
reconstruction. The laboratory provides access to an outstanding in house cryo-EM facility, which includes
a ThermoFisher Krios G4 paired with Gatan´s BioContinuum Imaging Filter and a K3 direct electron
detector. The facility also includes specimen preparation equipment and GPU-based computer clusters for
image processing and 3D reconstruction.

The project will be developed within the recently granted ERANET Neuron project IMatrix (https://www.neuron-eranet.eu/projects/IMatrix/ ). The main goal of the PhD project will be to design, prepare and validate smart or responsive contrast agents based on fluorinated nanoprobes and to study the role of metalloproteinases after stroke by 19F MRI. It is a multidisciplinary project involving chemistry, nanotechnology and biomedicine that will be carried out  the frame of an international consortium involving experts from Spain, France, Germany and Hungary. The project will be developed at the Instituto Biofisika (CSIC, UPV/EHU) (https://biofisika.org) under the supervision Dr. Mónica Carril in the FluoroNanoTools Lab.

We invite highly motivated candidates to apply for an immediately available postdoctoral position in the laboratory of Dr. Iban Ubarretxena at the Basque Centre for Biophysics (IBF; www.biofisika.org) in Leioa, Spain. Our laboratory employs cryo-electron microscopy (cryo-EM) to uncover the structure and function of proteins involved in human disease. For recent publications from the laboratory please see: Nature Commun. 2022 13:1050; Nature Commun. 2020 10:2699; Nat Struct Mol Biol. 2020 10:913; and Nat Struct Mol Biol. 2019 26:955.

A postdoctoral position is available at Instituto Biofisika Basque Centre for Biophysics under the supervision of Prof. Marité Cárdenas and Dr. Adai Colom. The position is fully funded and has a duration of 2 years.

It is recommended that applications are made as soon as possible as they will be considered upon arrival.

A position to do the PhD thesis is available at Instituto Biofisika Basque Centre for Biophysics under the supervision of Prof. Marité Cárdenas and Cesar Martin. The position is fully funded and has a duration of 3 years.

It is recommended that applications are made as soon as possible as they will be considered upon arrival.

We seek outstanding and highly‐talented applicants with a passion for a research career in life sciences. Applicants should hold a Master’s degree in Biochemistry, Molecular Biology, Biotechnology, Chemistry, Physics, Biomedicine or related disciplines. An excellent academic record to be competitive in PhD fellowship applications will be important. Fluency in English will also be important. The successful applicant will engage in high‐quality research leading to a PhD degree from the Molecular Biology and Biomedicine PhD program at the University of the Basque Country (UPV/EHU).

We are looking for candidates interested in completing a doctoral thesis in the group of Daniel Castaño Díez at the Instituto Biofisika-Fundación Biofísica Bizkaia at the Leioa Campus of the University of the Basque Country. The position is immediately available, and applications will be considered upon arrival.

The “Laboratory for Numerical Methods of Cryo Electron Tomography” is committed to the development of new computational approaches for the automated analysis and interpretation of three-dimensional images of cells and tissues. The thesis project will focus on the application of Deep Learning methodologies to locate and structurally characterize small proteins in their physiological environment. To this, we will implement state-of-the-art Image Processing techniques into our in-house software package Dynamo.

We invite highly motivated candidates to apply for an immediately available postdoctoral position in the laboratory of Vadim Frolov at Basque Centre for Biophysics (IBF; www.biofisika.org) in Bilbao, Spain.

Novel experimental approaches will be used, combining nanomanipulation, electrophysiology, and time-resolved fluorescence, confocal, and TIRF microscopy to characterize mechanical properties and dynamics of biomimetic and cell membranes under processes of remodeling.

A position to do the PhD thesis is available at Instituto Biofisika Basque Centre for Biophysics under the supervision of Prof. Marité Cárdenas and Dr. Mónica Carril. The position is fully funded and has a duration of 3 years.

It is recommended that applications are made as soon as possible as they will be considered upon arrival.

A position is available at Instituto Biofisika Basque Centre for Biophysics under the supervision of Dr. Jerome Solon (https://www.biofisika.org/en/research/biophysics-morphogenesis-laboratory).

The position would involve combination of experimental work and analysis to unravel the mechanism oftissue remodeling during Drosophila embryo development. This work will be performed in the Jerome Solon’s laboratory at the Biofisika Institute.

We are looking for people with a Bachelor's degree in Science (especially Chemistry or Physics) who have completed their Master's degree (or doing it this year), are motivated by experimental research and are interested in carrying out a multidisciplinary doctoral thesis.

Training is offered in advanced high-resolution spectroscopic techniques in one of the best equipped laboratories in Europe. The studies will be focused on biological molecules (sugars, drugs, pharmaceuticals...) and atmospheric science. The international doctoral thesis will be carried out in a multidisciplinary environment with the participation of several international groups, which will allow for stays-collaborations with these groups.

We are seeking two postdoctoral researchers promoting investigation and technological development in strategic areas. The positions are attached to a newly developed infrastructure, the Basque Resource for Image Analysis and Neural Networks (BRIANN), including different experts in Image Processing and Computational methods from different areas of Life Sciences

A postdoctoral position (2 years) is available at Instituto Biofisika. The selected candidate will join a collaborative project (NanoNeuro) with Dr. Mónica Carril (Instituto Biofisika), in close collaboration with Dr. Marek Grzelczak (CFM), Dr. Aitzol García-Etxarri (DIPC) and Prof. Rafael Yuste (Columbia University, DIPC), and will work in the functionalisation of hybrid nanomaterials for neuronal photo-stimulation.

We are looking for:

A motivated student with background in chemistry. Knowledge on nanotechnology and/or biomedicine will also be valued.

Good academic record in order to succeed in grant applications.

The candidate must hold a Master that gives access to doctoral studies.

We are looking for candidates with a PhD degree in Biochemistry, Molecular Biology, Biotechnology, Chemistry, Biomedicine or related disciplines.

The successful candidate must be skilled and experienced in heterologous protein expression in prokaryotic and eukaryotic systems (insect and mammalian cells), protein purification and initial biochemical/biophysical characterization (SEC-MALLS, DLS, circular dichroism, DSF, ITC, SPR), and sample preparation for structural studies (crystallization, specimen vitrification for cryo-electron microscopy).

The Basque Resource for Electron Microscopy (BREM) of the Fundación Biofísica Bizkaia and the Biofisika Institute (www.biofisika.org) in Bilbao (Basque Country in Spain) invites applications for a job in scientific computing.

BREM is a newly formed resource for high-resolution cryo-electron microscopy (cryo-EM) that houses a ThermoFisher Krios G4 cryo-electron microscope, equipped with a phase plate and Gatan´s BioContinuum Imaging Filter and K3 direct electron detector.

The successful candidate will be responsible for supporting high-performance computing infrastructure.

The Biofisika Institute (IBF) in Bilbao (Basque Country in Spain) invites applications for a cryo-electron microscopy (cryo-EM) scientific computing position. Candidates must hold a PhD degree in a relevant discipline with a focus on structural biology. The funding of the position is initially secured for up to two years; mid-term vision aims at offering the candidate a permanent contract.

The Instituto Biofisika (IBF) in Bilbao (Basque Country in Spain) invites applications for a permanent civil servant position as Research Technician in Quantitative Advanced Light Microscopy applied to biology.

This is a permanent civil servant position (Escala de Técnicos Superiores Especializados de Organismos Públicos de Investigación (Ref.37655)) sponsored by CSIC. The reference for this position is #23 Instrumentación en Biofísica – Instituto Biofisika.

To apply for this position you must register (€30.49 fee) for the selection process at www.administracion.gob.es/PAG/ips before February 3, 2021.

The position is available in the Structural Microbiology Laboratory led by Dr. David Albesa-Jové at the IBF-FBB (Bilbao, Spain).

Our group was established in October 2019 and focuses on understanding the biological function of virulence factors and essential enzymes in human pathogenic bacteria.

We seek a highly motivated individual with a BSc degree in Biochemistry obtained between 2019-2020, a publication record in structural biology, and a proficient English level.