Sonia Bañuelos

Researcher (UPV/EHU)

She earned her BSc in 1991 and PhD in 1995 from the University of the Basque Country, her thesis dealing with biophysical studies on membrane–protein interaction. She did postdoctoral research in M. Saraste´s group at the European Molecular Biology Laboratory (EMBL) in Heidelberg, working on structure and function of domains from cytoskeletal proteins. After having held a Ramón y Cajal contract, she is now researcher and lecturer at the University of the Basque Country. Her group is interested on the structure-function relationship and nucleo-cytoplasmic traffic of nucleophosmin, a protein altered in AML leukemia. Molecular interactions (e.g. with Crm1 exportin) are studied to gain insight into NPM functionality and involvement in pathogenesis.

Publications

Molecular Mechanisms Regulating the DNA Repair Protein APE1: A Focus on Its Flexible N-Terminal Tail Domain

D. J. López, J. A. Rodríguez, S. Bañuelos

Int. J. Mol. Sci. 2021, 22, DOI 10.3390/ijms22126308 (2021)
Nucleophosmin, a multifunctional nucleolar organizer with a role in DNA repair

López DJ, Rodríguez JA, Bañuelos S.

Biochim Biophys Acta Proteins Proteom. 1868(12):140532. (2020) doi: 10.1016/j.bbapap.2020.140532. (2020)
Nucleophosmin interaction with APE1: Insights into DNA repair regulation

López DJ, de Blas A, Hurtado M, García-Alija M, Mentxaka J, de la Arada I, Urbaneja MA, Alonso-Mariño M, Bañuelos S.

DNA Repair (Amst) 88:102809. (2020) doi: 10.1016/j.dnarep.2020.102809 (2020)
Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia

M.A. Urbaneja, L. Skjaerven, O. Aubi, J. Underhaug, D.J. Lopez, I. Arregi, M. Alonso-Marino, A. Cuevas, J.A. Rodriguez, A. Martinez and S. Banuelos

Sci Rep 7, 13959 doi: 10.1038/s41598-017-14497-4 (2017)
A celular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K

I. García-Santisteban, I. Arregi, M. Alonso-Mariño, M.A. Urbaneja, J.J. Garcia-Vallejo, S. Bañuelos and J.A. Rodríguez

Cell Mol Life Sci. 73, 4685-4699 (2016)
Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport

Arregi I, Falces J, Olazabal-Herrero A, Alonso-Mariño M, Taneva SG, Rodríguez JA, Urbaneja MA y Bañuelos S

PLoS ONE 10(6): e0130610. doi:10.1371/journal.pone.0130610 (2015)
Recognition of intermolecular G-quadruplexes by full length nucleophosmin. Effect of a leukaemia-associated mutation.

S. Bañuelos, B. Lectez, S.G. Taneva, G. Ormaza, M. Alonso-Mariño, X. Calle and M.A. Urbaneja.

FEBS Lett. 587, 2254–2259 (2013).
Thermodynamic signatures of macromolecular complexes-insights on the stability and interactions of nucleoplasmin, a nuclear chaperone.

S.G. Taneva, S. Bañuelos and M.A. Urbaneja.

In: Applications of Calorimetry in a Wide Context - Differential Scanning Calorimetry, Isothermal Titration Calorimetry and Microcalorimetry. Chapter 7, Intech, Rijeta, Croatia, 153-182 (2013).
A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family.

I. García-Santisteban, S. Bañuelos and J.A. Rodríguez.

Biochem. J. 441, 209–217 (2012).
The nuclear transport machinery recognizes nucleoplasmin-histone complexes.

I. Arregui, J. Falces, S. Bañuelos, M.A. Urbaneja and S.G. Taneva.

Biochemistry 50, 7104-7110 (2011).