Maier Lorizate

Associate Lecturer (UPV/EHU)

She earned her Bachelor of Science in 2001 and Master of Science in 2003 from the University of the Basque Country (UPV/EHU) and the PhD in 2006 from the University of Basque Country (UPV/EHU). She did postdoctoral research at the University of Heidelberg (Germany) working on the dynamics of cellular membranes in the context of HIV pathogenesis, the study of novel therapies for HIV infection treatment, and the role of viral lipids in virus stability and infectivity. She got a full professor position in 2012.

My research aims at investigating different aspects of HIV pathogenesis, especially in the role that lipids and lipid-protein interactions play in virus entry and morphogenesis. We also focus on the development of novel drug delivery systems and therapeutic strategies to fight or prevent HIV infection.

Publications

Cholesterol in the Viral Membrane is a Molecular Switch Governing HIV-1 Env Clustering

Nieto-Garai JA, Arboleya A, Otaegi S, Chojnacki J, Casas, J, Fabrias G, Contreras FX, Krausslich HG, Lorizate M.

Advanced Science. 2003468. (2020) doi: 10.1002/advs.202003468 (2020)
Lipidomimetic Compounds Act as HIV-1 Entry Inhibitors by Altering Viral Membrane Structure

Nieto-Garai JA, Glass B, Bunn C, Giese M, Jennings G, Brankatschk B, Agarwal S, Börner K, Contreras FX, Knölker HJ, Zankl C, Simons K, Schroeder C, Lorizate M, Kräusslich HG.

Front Immunol. 2018 ;9:1983. doi: 10.3389/fimmu.2018.01983. eCollection 2018. (2018)
Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif

L.M. Molinos-Albert, E. Bilbao, L. Agullo, S. Marfil, E. Garcia, M.L.R. de la Concepcion, N. Izquierdo-Useros, C. Vilaplana, J.A. Nieto-Garai, F.X. Contreras, M. Floor, P.J. Cardona, J. Martinez-Picado, B. Clotet, J. Villa-Freixa, M. Lorizate, J. Carrillo and J. Blanco

Sci Rep 7, 40800 doi: 10.1038/srep40800 (2017)
Functional organizacion of the HIV lipid envelope

N. Huarte, P. Carravilla, A. Cruz, M. Lorizate, J.A. Nieto-Garai, H.G. Kräusslich, J. Perez-Gil, J.M. Requejo and J.L. Nieva

Sci Rep 6 34190. doi: 10.1038/srep34190 (2016)
HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1.

Nuria Izquierdo-Useros, Maier Lorizate, Paul J. McLaren, Amalio Telenti, Hans-Georg Krausslich, Javier Martinez-Picado ,

PLoS Pathog. 10:e1004146 (2014).
Comparative lipidomics analysis of HIV-1 particles and their producer cell membrane in different cell lines.

M. Lorizate, T. Sachsenheimer, B. Glass, A. Habermann, M.J. Gerl, H.G. Kräusslich and B. Brügger.

Cell Microbiol. 15, 292-304 (2013).
Recognition of membrane-bound fusion-peptide/MPER complexes by the HIV-1 neutralizing 2F5 antibody: implications for Anti-2F5 immunogenicity.

N. Huarte, A. Araujo, R. Arranz, M. Lorizate, H. Quendler, R. Kunert, J.M. Valpuesta and J.L. Nieva.

PLoS One, 7, e52740. doi: 10.1371 (2012).
Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides.

N. Izquierdo-Useros, M. Lorizate, M.C. Puertas, M.T. Rodriguez-Plata, N. Zangger, E. Erikson, M. Pino, I. Erkizia, B. Glass, B. Clotet, O.T. Keppler, A. Telenti, H.G. Kräusslich and J. Martinez-Picado.

PLoS Biol. 10(12):e1001448. doi: 10.1371/journal.pbio.1001448 (2012).
Sialyllactose in viral membrane gangliosides is a novel molecular recognition pattern for mature dendritic cell capture of HIV-1.

N. Izquierdo-Useros, M. Lorizate, F.X. Contreras, M.T. Rodriguez-Plata, B. Glass, I. Erkizia, J.G. Prado, J. Casas, G. Fabriàs, H.G. Kräusslich and J. Martinez-Picado.

PLoS Biol.10(4):e1001315. doi: 10.1371/journal.pbio.1001315 (2012).