Covadonga Malo
Laboratory technician
Publications
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An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel
J. Urrutia, A. Aguado, C. Gomis-Perez, A. Muguruza-Montero, O. R. Ballesteros, J. Zhang, E. Nuñez, C. Malo, H. J. Chung, A. Leonardo, A. Bergara, A. Villarroel
BMC Biol. 2021, 19, DOI 10.1186/s12915-021- 01040-1. (2021)
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The Crossroad of Ion Channels and Calmodulin in Disease
Urrutia J, Aguado A, Muguruza-Montero A, Núñez E, Malo C, Casis O, Villarroel A.
Int J Mol Sci. 20(2). pii: E400. doi: 10.3390/ijms20020400. (2019)
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Homomeric Kv7.2 current suppression is a common feature in KCNQ2 epileptic encephalopathy
C Gomis-Pérez, J Urrutia, A Marcé-Grau, C Malo, E López-Laso, A Felipe-Rucián, M Raspall-Chaure, A Macaya, A Villarroel.
Epilepsia. 60(1):139-148. doi: 10.1111/epi.14609 (2019)
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Lack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutants
Alaimo A, Etxeberria A, Gómez-Posada JC, Gomis-Perez C, Fernández-Orth J, Malo C, Villarroel A.
Channels (Austin) 12, 299-310. doi: 10.1080/19336950.2018.1511512 (2018)
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Structural basis and energy landscape for the Ca2+ gating and calmodulation of the Kv7.2 K+ channel
Bernardo-Seisdedos G, Nuñez E, Gomis-Perez C, Malo C, Villarroel Á, Millet O.
Proc Natl Acad Sci U S A. 2018;115(10):2395-2400. doi:10.1073/pnas.1800235115. Erratum in: Proc Natl Acad Sci U S A. 2018;115(15):E3599. doi: 10.1073/pnas.1804137115 (2018)
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Calmodulin confers calcium sensitivity to the stability of the distal intracellular assembly domain of Kv7.2 channels
A. Alaimo, E. Nunez, P. Aivar, J. Fernandez-Orth, C. Gomis-Perez, G. Bernardo-Seisdedos, C. Malo and A. Villarroel
Sci Rep 7, 13425 doi: 10.1038/s41598-017-13811-4 (2017)
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Uncoupling PIP2-calmodulin regulation of Kv7.2 channels by an assembly de-stabilizing epileptogenic mutation
Alberdi A, Gomis-Perez C, Bernardo-Seisdedos G, Alaimo A, Malo C, Aldaregia J, Lopez-Robles C, Areso P, Butz E, Wahl-Schott C, Villarroel A
J Cell Sci. 28:4014-23 (2015)
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An unconventional calmodulin anchoring site within the AB module of Kv7.2 channels
Gomis-Perez C, Alaimo A, Fernandez-Orth J, Alberdi A, Aivar-Mateo P, Bernardo-Seisdedos G, Malo C, Areso P, Felipe A, Villarroel A
J Cell Sci. 128:3155-63 (2015)
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Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding.
M.A. Bonache, A. Alaimo, C. Malo, O. Millet, A. Villarroel and R. González-Muñiz.
Org Biomol Chem. 12, 8877-8887 (2014).
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The ever changing moods of calmodulin: how structural plasticity entails transductional adaptability.
A. Villarroel, M. Taglialatela, G. Bernardo-Seisdedos, A. Alaimo, J. Agirre, A. Alberdi, C. Gomis-Pérez, M.V. Soldovieri, P. Ambrosino, C. Malo and P. Areso.
J Mol Biol. 426, 2717-2735 (2014).
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Pivoting between calmodulin lobes triggered by calcium in the Kv7.2/calmodulin complex.
A. Alaimo, A. Alberdi, C. Gomis-Pérez, J. Fernández-Orth, G. Bernardo-Seisdedos, C. Malo, O. Millet, P. Areso and Á. Villarroel.
PLoS One, Volume 9 | Issue 1 | e86711 (2014).
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The use of dansyl-calmodulin to study interactions with channels and other proteins.
A. Alaimo, C. Malo, P. Areso, K. Aloria, O. Millet and A. Villarroel.
Methods Mol. Biol. 998, 217-231 (2013).