Phone. +34-946013225

Álvaro Villarroel

Staff scientist (CSIC)

Publications

• An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel

  J. Urrutia, A. Aguado, C. Gomis-Perez, A. Muguruza-Montero, O. R. Ballesteros, J. Zhang, E. Nuñez, C. Malo, H. J. Chung, A. Leonardo, A. Bergara, A. Villarroel

  BMC Biol. 2021, 19, DOI 10.1186/s12915-021- 01040-1. (2021)

• Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors

  Alaimo A, Lorenzoni M, Ambrosino P, Bertossi A, Bisio A, Macchia A, Zoni E, Genovesi S, Cambuli F, Foletto V, De Felice D, Soldovieri MV, Mosca I, Gandolfi F, Brunelli M, Petris G, Cereseto A, Villarroel A, Thalmann G, Carbone FG, Kruithof-de Julio M, Barbareschi M, Romanel A, Taglialatela M, Lunardi A.

  Cell Death Dis. 11(12):1039. (2020) doi: 10.1038/s41419-020-03256-5. (2020)

• Novel Dominant KCNQ2 Exon 7 Partial In-Frame Duplication in a Complex Epileptic and Neurodevelopmental Delay Syndrome

  Lazo PA, García JL, Gómez-Puertas P, Marcos-Alcalde Í, Arjona C, Villarroel A, González-Sarmiento R, Fons C.

  Int J Mol Sci. 21(12):4447. (2020) doi: 10.3390/ijms21124447. (2020)

• Atomistic Insights of Calmodulin Gating of Complete Ion Channels

  Núñez E, Muguruza-Montero A, Villarroel A.

  Int J Mol Sci. 21(4). pii: E1285. (2020) doi: 10.3390/ijms21041285. (2020)

• The Crossroad of Ion Channels and Calmodulin in Disease

  Urrutia J, Aguado A, Muguruza-Montero A, Núñez E, Malo C, Casis O, Villarroel A.

  Int J Mol Sci. 20(2). pii: E400. doi: 10.3390/ijms20020400. (2019)

• Homomeric Kv7.2 current suppression is a common feature in KCNQ2 epileptic encephalopathy

  C Gomis-Pérez, J Urrutia, A Marcé-Grau, C Malo, E López-Laso, A Felipe-Rucián, M Raspall-Chaure, A Macaya, A Villarroel.

  Epilepsia. 60(1):139-148. doi: 10.1111/epi.14609 (2019)

• Lack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutants

  Alaimo A, Etxeberria A, Gómez-Posada JC, Gomis-Perez C, Fernández-Orth J, Malo C, Villarroel A.

  Channels (Austin) 12, 299-310. doi: 10.1080/19336950.2018.1511512 (2018)

• Calmodulin: A Multitasking Protein in Kv7.2 Potassium Channel Functions

  Alaimo A, Villarroel A.

  Biomolecules 8, pii: E57. doi: 10.3390/biom8030057 (2018)

• Structural basis and energy landscape for the Ca2+ gating and calmodulation of the Kv7.2 K+ channel

  Bernardo-Seisdedos G, Nuñez E, Gomis-Perez C, Malo C, Villarroel Á, Millet O.

  Proc Natl Acad Sci U S A. 2018;115(10):2395-2400. doi:10.1073/pnas.1800235115. Erratum in: Proc Natl Acad Sci U S A. 2018;115(15):E3599. doi: 10.1073/pnas.1804137115 (2018)

• Calmodulin confers calcium sensitivity to the stability of the distal intracellular assembly domain of Kv7.2 channels

  A. Alaimo, E. Nunez, P. Aivar, J. Fernandez-Orth, C. Gomis-Perez, G. Bernardo-Seisdedos, C. Malo and A. Villarroel

  Sci Rep 7, 13425 doi: 10.1038/s41598-017-13811-4 (2017)

• Differential Regulation of PI(4,5)P-2 Sensitivity of Kv7.2 and Kv7.3 Channels by calmodulin

  C. Gomis-Perez, M.V. Soldovieri, C. Maio, P. Ambrosino, M. Taglialatela, P. Areso and A.Villarroel

  Front Mol Neurosci 10, 117 doi: 10.3389/fnmol.2017.0011 (2017)

• Dynamic properties of calcium-activated chloride currents in Xenopus laevis oocytes

  I.M. De la Fuente, I. Malaina, A. Perez-Samartin, M.D. Boyano, G. Perez-Yarza, C. Bringas, A. Villarroel, M. Fedetz, R. Arellano, J.M. Cortes and L. Martinez

  Sci Rep 7, 41791 doi: 10.1038/srep41791 (2017)

• Ubiquitin-specific protease 36 (USP36) controls neuronal precursor cell-expressed developmentally down-regulated 4-2 (Nedd4-2) actions over the neurotrophin receptor TrkA and potassium voltage-gated channels 7.2/3 (Kv7.2/3)

  B. Anta, C. Martín-Rodríguez, C. Gomis-Perez, L. Calvo, S. López-Benito, A.A. Calderón-García, C. Vicente-García, A. Villarroel and J.C. Arévalo

  J Biol Chem. 291, 19132-19145 (2016)

• Uncoupling PIP2-calmodulin regulation of Kv7.2 channels by an assembly de-stabilizing epileptogenic mutation

  Alberdi A, Gomis-Perez C, Bernardo-Seisdedos G, Alaimo A, Malo C, Aldaregia J, Lopez-Robles C, Areso P, Butz E, Wahl-Schott C, Villarroel A

  J Cell Sci. 28:4014-23 (2015)

• Epilepsy-causing mutations in Kv7.2 C-terminus affect binding and functional modulation by calmodulin

  Ambrosino P, Alaimo A, Bartollino S, Manocchio L, De Maria M, Mosca I, Gomis-Perez C, Alberdi A, Scambia G, Lesca G, Villarroel A, Taglialatela M, Soldovieri MV

  Biochimica et Biophysica Acta Biomembranes 1852:1856-1866 (2015)

• An unconventional calmodulin anchoring site within the AB module of Kv7.2 channels

  Gomis-Perez C, Alaimo A, Fernandez-Orth J, Alberdi A, Aivar-Mateo P, Bernardo-Seisdedos G, Malo C, Areso P, Felipe A, Villarroel A

  J Cell Sci. 128:3155-63 (2015)