Phone. +34-946013225

Álvaro Villarroel

Staff scientist (CSIC)

Publications

• The Crossroad of Ion Channels and Calmodulin in Disease

  Urrutia J, Aguado A, Muguruza-Montero A, Núñez E, Malo C, Casis O, Villarroel A.

  Int J Mol Sci. 20(2). pii: E400. doi: 10.3390/ijms20020400. (2019)

• Homomeric Kv7.2 current suppression is a common feature in KCNQ2 epileptic encephalopathy

  C Gomis-Pérez, J Urrutia, A Marcé-Grau, C Malo, E López-Laso, A Felipe-Rucián, M Raspall-Chaure, A Macaya, A Villarroel.

  Epilepsia. 60(1):139-148. doi: 10.1111/epi.14609 (2019)

• Lack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutants

  Alaimo A, Etxeberria A, Gómez-Posada JC, Gomis-Perez C, Fernández-Orth J, Malo C, Villarroel A.

  Channels (Austin) 12, 299-310. doi: 10.1080/19336950.2018.1511512 (2018)

• Calmodulin: A Multitasking Protein in Kv7.2 Potassium Channel Functions

  Alaimo A, Villarroel A.

  Biomolecules 8, pii: E57. doi: 10.3390/biom8030057 (2018)

• Structural basis and energy landscape for the Ca2+ gating and calmodulation of the Kv7.2 K+ channel

  Bernardo-Seisdedos G, Nuñez E, Gomis-Perez C, Malo C, Villarroel Á, Millet O.

  Proc Natl Acad Sci U S A. 2018;115(10):2395-2400. doi:10.1073/pnas.1800235115. Erratum in: Proc Natl Acad Sci U S A. 2018;115(15):E3599. doi: 10.1073/pnas.1804137115 (2018)

• Calmodulin confers calcium sensitivity to the stability of the distal intracellular assembly domain of Kv7.2 channels

  A. Alaimo, E. Nunez, P. Aivar, J. Fernandez-Orth, C. Gomis-Perez, G. Bernardo-Seisdedos, C. Malo and A. Villarroel

  Sci Rep 7, 13425 doi: 10.1038/s41598-017-13811-4 (2017)

• Differential Regulation of PI(4,5)P-2 Sensitivity of Kv7.2 and Kv7.3 Channels by calmodulin

  C. Gomis-Perez, M.V. Soldovieri, C. Maio, P. Ambrosino, M. Taglialatela, P. Areso and A.Villarroel

  Front Mol Neurosci 10, 117 doi: 10.3389/fnmol.2017.0011 (2017)

• Dynamic properties of calcium-activated chloride currents in Xenopus laevis oocytes

  I.M. De la Fuente, I. Malaina, A. Perez-Samartin, M.D. Boyano, G. Perez-Yarza, C. Bringas, A. Villarroel, M. Fedetz, R. Arellano, J.M. Cortes and L. Martinez

  Sci Rep 7, 41791 doi: 10.1038/srep41791 (2017)

• Ubiquitin-specific protease 36 (USP36) controls neuronal precursor cell-expressed developmentally down-regulated 4-2 (Nedd4-2) actions over the neurotrophin receptor TrkA and potassium voltage-gated channels 7.2/3 (Kv7.2/3)

  B. Anta, C. Martín-Rodríguez, C. Gomis-Perez, L. Calvo, S. López-Benito, A.A. Calderón-García, C. Vicente-García, A. Villarroel and J.C. Arévalo

  J Biol Chem. 291, 19132-19145 (2016)

• Uncoupling PIP2-calmodulin regulation of Kv7.2 channels by an assembly de-stabilizing epileptogenic mutation

  Alberdi A, Gomis-Perez C, Bernardo-Seisdedos G, Alaimo A, Malo C, Aldaregia J, Lopez-Robles C, Areso P, Butz E, Wahl-Schott C, Villarroel A

  J Cell Sci. 28:4014-23 (2015)

• Epilepsy-causing mutations in Kv7.2 C-terminus affect binding and functional modulation by calmodulin

  Ambrosino P, Alaimo A, Bartollino S, Manocchio L, De Maria M, Mosca I, Gomis-Perez C, Alberdi A, Scambia G, Lesca G, Villarroel A, Taglialatela M, Soldovieri MV

  Biochimica et Biophysica Acta Biomembranes 1852:1856-1866 (2015)

• An unconventional calmodulin anchoring site within the AB module of Kv7.2 channels

  Gomis-Perez C, Alaimo A, Fernandez-Orth J, Alberdi A, Aivar-Mateo P, Bernardo-Seisdedos G, Malo C, Areso P, Felipe A, Villarroel A

  J Cell Sci. 128:3155-63 (2015)