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• Bionanotechnology as a Tool for Drug Delivery
• Lipid-Protein Interactions in Cellular Processes
• Sphingolipids and Membrane Domains
• Inter-Domain Relationships in Integral Membrane Proteins

• The interaction of Aβ42 peptide in monomer, oligomer or fibril forms with sphingomyelin/cholesterol/ganglioside bilayers

  Ahyayauch H, Masserini M, Goñi FM, Alonso A.

  Int J Biol Macromol. S0141-8130(20)35037-6. doi: 10.1016/j.ijbiomac.2020.11.112. (2021)

• Phase-selective staining of model and cell membranes, lipid droplets and lipoproteins with fluorescent solvatochromic pyrene probes

  Sot J, Esnal I, Monasterio BG, León-Irra R, Niko Y, Goñi FM, Klymchenko A, Alonso A.

  Biochim Biophys Acta Biomembr. 1863(1):183470. (2021) doi: 10.1016/j.bbamem.2020.183470. (2021)

• β-Amyloid (1-42) peptide adsorbs but does not insert into ganglioside-containing phospholipid membranes in the liquid-disordered state: modelling and experimental studies

  Ahyayauch H, García-Arribas AB, Masserini ME, Pantano S, Goñi FM, Alonso A.

  Int J Biol Macromol. 164:2651-2658. (2020) doi: 10.1016/j.ijbiomac.2020.08.165. (2020)

• Exploring polar headgroup interactions between sphingomyelin and ceramide with infrared spectroscopy

  de la Arada I, González-Ramírez EJ, Alonso A, Goñi FM, Arrondo JR.

  Sci Rep. 10(1):17606. (2020) doi: 10.1038/s41598-020-74781-8. (2020)

• Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation

  Fernández-Ramos D, Lopitz-Otsoa F, Delacruz-Villar L, Bilbao J, Pagano M, Mosca L, Bizkarguenaga M, Serrano-Macia M, Azkargorta M, Iruarrizaga-Lejarreta M, Sot J, Tsvirkun D, van Liempd SM, Goni FM, Alonso C, Martínez-Chantar ML, Elortza F, Hayardeny L, Lu SC, Mato JM.

  World J Gastroenterol 26(34):5101-5117. (2020) doi: 10.3748/wjg.v26.i34.5101. (2020)

• C24:0 and C24:1 sphingolipids in cholesterol-containing, five- and six-component lipid membranes

  González-Ramírez EJ, García-Arribas AB, Sot J, Goñi FM, Alonso A.

  Sci Rep. 10(1):14085. (2020) doi: 10.1038/s41598-020-71008-8. (2020)

• A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis

  Barth ND, Subiros-Funosas R, Mendive-Tapia L, Duffin R, Shields MA, Cartwright JA, Henriques ST, Sot J, Goñi FM, Lavilla R, Marwick JA, Vermeren S, Rossi AG, Egeblad M, Dransfield I, Vendrell M.

  Nat Commun. 11(1):4027. (2020) doi: 10.1038/s41467-020-17772-7. (2020)

• Plasma lipids are associated with white matter microstructural changes and axonal degeneration

  Iriondo A, García-Sebastian M, Arrospide A, Arriba M, Aurtenetxe S, Barandiaran M, Clerigue M, Ecay-Torres M, Estanga A, Gabilondo A, Izagirre A, Saldias J, Tainta M, Villanua J, Mar J, Goñi FM, Martínez-Lage P.

  Brain Imaging Behav. (2020). doi: 10.1007/s11682-020-00311-9. Online ahead of print. (2020)

• Cerebrospinal Fluid 7-Ketocholesterol Level is Associated with Amyloid-β42 and White Matter Microstructure in Cognitively Healthy Adults

  Iriondo A, García-Sebastian M, Arrospide A, Arriba M, Aurtenetxe S, Barandiaran M, Clerigue M, Ecay-Torres M, Estanga A, Gabilondo A, Izagirre A, Saldias J, Tainta M, Villanua J, Blennow K, Zetterberg H, Mar J, Abad-García B, Dias IHK, Goñi FM, Martínez-Lage P.

  J Alzheimers Dis. 76(2):643-656 (2020). doi: 10.3233/JAD-200105. (2020)

• Patches and Blebs: A Comparative Study of the Composition and Biophysical Properties of Two Plasma Membrane Preparations from CHO Cells

  Monasterio BG, Jiménez-Rojo N, García-Arribas AB, Riezman H, Goñi FM, Alonso A.

  Int J Mol Sci. 21(7). pii: E2643. (2020) doi: 10.3390/ijms21072643. (2020)

• The Binding of Aβ42 Peptide Monomers to Sphingomyelin/Cholesterol/Ganglioside Bilayers Assayed by Density Gradient Ultracentrifugation

  Ahyayauch H, de la Arada I, Masserini ME, Arrondo JLR, Goñi FM, Alonso A.

  Int J Mol Sci. 21(5). pii: E1674. (2020) doi: 10.3390/ijms21051674. (2020)

• Photoacoustic effect applied on model membranes and living cells: direct observation with multiphoton excitation microscopy and long-term viability analysis

  Galisteo-González F, Monasterio BG, Gil D, Valle M, Goñi FM.

  Sci Rep. 10(1):299. (2020) doi: 10.1038/s41598-019-56799-9. (2020)

• Reflections on BBRC

  Goñi FM.

  Biochem Biophys Res Commun. 520(4):676. (2019) doi: 10.1016/j.bbrc.2019.10.003. (2019)

• Mixing brain cerebrosides with brain ceramides, cholesterol and phospholipids

  González-Ramírez EJ, Goñi FM, Alonso A.

  Sci Rep. 9(1):13326. (2019) doi: 10.1038/s41598-019-50020-7. (2019)

• Fast and slow biomembrane solubilizing detergents: Insights into their mechanism of action

  Lete MG, Monasterio BG, Collado MI, Medina M, Sot J, Alonso A, Goñi FM.

  Colloids Surf B Biointerfaces. ;183:110430. (2019) doi: 10.1016/j.colsurfb.2019.110430. (2019)

• Lamellar Phases Composed of Phospholipid, Cholesterol, and Ceramide, as Studied by 2H NMR

  Siavashi R, Phaterpekar T, Leung SSW, Alonso A, Goñi FM, Thewalt JL.

  Biophys J. pii: S0006-3495(19)30497-7. doi: 10.1016/j.bpj.2019.05.027. [Epub ahead of print] (2019)

• Homogeneous and Heterogeneous Bilayers of Ternary Lipid Compositions Containing Equimolar Ceramide and Cholesterol

  González-Ramírez EJ, Artetxe I, García-Arribas AB, Goñi FM, Alonso A.

  Langmuir 35(15):5305-5315. doi: 10.1021/acs.langmuir.9b00324 (2019)

• Isopropanol extraction for cerebrospinal fluid lipidomic profiling analysis

  A Iriondo, M Tainta, J Saldias, M Arriba, B Ochoa, FM Goñi, P Martinez-Lage, B Abad-García.

  Talanta. 195:619-627. doi: 10.1016/j.talanta.2018.11.101 (2019)

• The interaction of lipid-liganded gold clusters (Aurora ™) with lipid bilayers

  J Sot J, SA Mendanha-Neto SA, JV Busto JV, AB García-Arribas, S Li, SW Burgess, WA Shaw, D Gil-Carton, FM Goñi, A Alonso.

  Chem Phys Lipids. 218:40-46. doi: 10.1016/j.chemphyslip.2018.11.007 (2019)

• Rafts: A nickname for putative transient nanodomains

  FM Goñi.

  Chem Phys Lipids.;218:34-39. doi: 10.1016/j.chemphyslip.2018.11.006 (2019)

• The fatty acids of sphingomyelins and ceramides in mammalian tissues and cultured cells: Biophysical and physiological implications

  MM Manni, J Sot, E Arretxe, R Gil-Redondo, JM Falcón-Pérez, D Balgoma, C Alonso, FM Goñi, A Alonso.

  Chem Phys Lipids. 217:29-34. doi:10.1016/j.chemphyslip.2018.09.010 (2018)

• Omega-3 polyunsaturated fatty acids do not fluidify bilayers in the liquid-crystalline state

  A De Santis, Y Varela, J Sot, G D\'Errico, FM Goñi, A Alonso.

  Sci Rep. 8(1):16240. doi: 10.1038/s41598-018-34264-3 (2018)

• Clearly Detectable, Kinetically Restricted Solid−Solid Phase Transition in cis-Ceramide Monolayers

  Fanani ML, Busto JV, Sot J, Abad JL, Fabrías G, Saiz L, Vilar JMG, Goñi FM, Maggio B, Alonso A.

  Langmuir; 34(39):11749-11758. doi: 10.1021/acs.langmuir.8b02198. (2018)

• Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells

  Ahyayauch H, García-Arribas AB, Sot J, González-Ramírez EJ, Busto JV, Monasterio BG, Jiménez-Rojo N, Contreras FX, Rendón-Ramírez A, Martin C, Alonso A, Goñi FM.

  Sci Rep. 8, 7456. doi: 10.1038/s41598-018-25905-8 (2018)

• The Physical Properties of Ceramides in Membranes

  Alonso A, Goñi FM.

  Annu Rev Biophys. 2018. doi: 10.1146/annurev-biophys-070317-033309 (2018)

• Phase behavior of palmitoyl and egg sphingomyelin

  Arsov Z, Gonzalez-Ramirez EJ, Goni FM, Tristram-Nagle S, Nagle J.

  Chemistry and Physics of Lipids 2018 (2018)

• Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge

  J.H. Hervas, A. Landajuela, Z. Anton, A.V. Shnyrova, F.M. Goni and A. Alonso

  Sci Rep 7, 15614 doi: 10.1038/s41598-017-15057-6 (2017)

• Purification and characterization of the colicin A immunity protein in detergent micelles

  A. Metola, A.M. Bouchet, M. Alonso-Marino, T. Diercks, L. Maler, F.M. Goni and A.R. Viguera

  Biochim Biophys Acta 1859, 2181-2192 doi: 10.1016/j.bbamem.2017.08.007 (2017)

• Coating Graphene Oxide with Lipid Bilayers Greatly Decreases Its Hemolytic Properties

  B.G, Monasterio, B. Alonso, J. Sot, A.B. Garcia-Arribas, D. Gil-Carton, M. Valle, A. Zurutuza and F.M. Goni

  Langmuir 33, 8181-8191 doi: 10.1021/acs.langmuir.7b0155 (2017)

• Polyamine-RNA-membrane interactions: From the past to the future in biology

  C. Acosta-Andrade, I. Artetxe, M.G. Lete, B.G. Monasterio, K. Ruiz-Mirazo, F.M. Goni and F. Sanchez-Jimenez

  Colloids Surf B Biointerfaces 155, 173-181 doi: 10.1016/j.colsurfb.2017.04.005 (2017)

• Complex Effects of 24:1 Sphingolipids in Membranes Containing Dioleoylphosphatidylcholine and Cholesterol

  A.B. Garcia-Arribas, E.J. Gonzalez-Ramirez, J. Sot, I. Areso, A. Alonso and F.M. Goni

  Langmuir 33, 5545-5554 doi: 10.1021/acs.langmuir.7b00162 (2017)

• The conformation of human phospholipid scramblase 1, as studied by infrared spectroscopy. Effects of calcium and detergent

  N. Andraka, L. Sanchez-Magraner, M. Garcia-Pacios, F.M. Goni and J.L.R. Arrondo

  Biochim Biophys Acta 1859, 1019-1028 doi: 10.1016/j.bbamem.2017.02.015 (2017)

• Lipidomic profile of GM95 cell death induced by Clostridium perfringens alpha-toxin

  M.M. Manni, J.G. Valero, M. Perez-Cormenzana, A. Cano, C. Alonso and F.M. Goni

  Chem phys Lipids 203, 54-70 doi: 10.1016/j.chemphyslip.2017.01.002 (2017)

• Membrane-assisted viral DNA ejection

  I. Santos-Perez, H.M. Oksanen, D.H. Bamford, F.M. Goni, D. Reguera and N.G.A. Abrescia

  Biochim Biophys Acta 1861, 664-672 doi: 10.1016/j.bbagen.2016.12.013 (2017)

• A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

  R. Subiros-Funosas, L. Mendive-Tapia, J. Sot, J.D. Pound, N. Barth, Y. Varela, F.M. Goni, M. Paterson, C.D. Gregory, F. Albericio, I. Dransfield, R. Lavilla and M. Vendrell

  Chem Commun 53, 945-948 doi: 10.1039/c6cc07879f (2017)

• Lipid-modified oligonucleotide conjugates: Insights into gene silencing, interaction with model membranes and cellular uptake mechanisms

  B. Ugarte-Uribe, S. Grijalvo, S.N. Pertinez, J.V. Busto, C. Martin, A. Alagia, F.M. Goni, R. Eritja and I. Alkorta

  Bioorg Med Chem 25, 175-186 doi: 10.1016/j.bmc.2016.10.024 (2017)

• Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP

  Z. Anton, A. Landajuela, J.H. Hervas, L.R. Montes, S. Hernandez-Tiedra, G. Velasco, F.M Goñi and A. Alonso

  Autophagy. 12, 2386-2403 (2016)

• Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

  S. Hernández-Tiedra, G. Fabriàs, D. Dávila, I.J. Salanueva, J. Casas, L.R. Montes, Z. Antón, E. García-Taboada, M. Salazar-Roa, M. Lorente, J. Nylandsted, J. Armstrong, I. López-Valero, C.S. McKee, A. Serrano-Puebla, R. García-López, J. González-Martínez, J.L. Abad, K. Hanada, P. Boya, F.M. Goñi, M. Guzmán, P. Lovat, M. Jäättelä, A. Alonso and G. Velasco

  Autophagy. 12, 2213-2229. (2016)

• Cholesterol interactions with ceramide and sphingomyerlin

  A.B. García-Arribas, A. Alonso and F.M. Goñi

  Chem Phys Lipids. 199, 26-34 (2016)

• Ceramide-induced lamellar gel phases in fluid cell lipid extracts

  A.B. Garcia-Arribas, H. Ahyayauch, J. Sot, P.L. Lopez-Gonzalez, A. Alonso and F.M. Goñi

  Langmuir 32, 9053-9063 (2016)

• Cholesterol-ceramide interactions in phospholipid and sphingolipid bilayers as observed by positron annihilation lifetime spectroscopy and molecular dynamics simulations

  A.B. García Arribas, R. Axpe, J.I. Mujika, D. Mérida, J.V. Busto, J. Sot, A. Alonso, X. Lopez, J.A. García, J.M. Ugalde, F. Plazaola and F.M. Goñi

  Langmuir. 32, 5434-5444 (2016)

• Thermotropic properties of ceramides in aqueous or lipidic environments

  A. Alonso and F.M. Goñi

  Book article CRC Press, Boca Raton, FL, USA, pp. 137-151 (2016)

• Approaches to polyunsaturated sphingolipids: new conformationally restrained analogs with minimal structural modifications

  I. Nieves, J.L. Abad, L.R. Montes, F.M. Goñi and A. Delgado

  Tetrahedron 72, 237-265 (2016)

• Lipid geometry and bilayer curvature modulate LC3/GABARAP-mediated model autophagosomal elongation

  A. Landajuela, J.H. Hervas, Z. Anton, L.R. Montes, D. Gil, M. Valle, J.F. Rodriguez, F. M. Goñi and A. Alonso

  Biophys J. 110, 411–422 (2016)

• Thermally-induced aggregation and fusion of protein-free lipid vesicles

  Ibarguren M, Bomans Ph, Ruiz-Mirazo K, Frederik PM, Alonso A, Goñi FM

  Colloid Surface B. 136:545-52 (2015)

• Solid lipid nanoparticles for delivery of Calendula officinalis extract

  Arana L, Salado C, Vega S, Aizpurua-Olaizola O, Arada I, Suarez T, Usobiaga A, Arrondo JL, Alonso A, Goni FM, Alkorta I

  Colloid Surface B. 135:18-26 (2015)

• Lipids that determine detergent resistance of MDCK cell membrane fractions

  Manni MM, Cano A, Alonso C, Goñi FM

  Chem Phys Lipids. 191:68-74 (2015)

• Lipidic nanovesicles stabilize suspensions of metal oxide nanoparticles

  Jimenez-Rojo N, Lete MG, Rojas E, Gil D, Valle M, Alonso A, Moya SE, Goñi FM

  Chem Phys Lipids. 191:84-90 (2015)

• C8-glycosphingolipids preferentially insert into tumor cell membranes and promote chemotherapeutic drug uptake

  Cordeiro Pedrosa LR, Van Cappellen WA, Steurer B, Ciceri D, ten Hagen TL, Eggermont AM, Verheij M, Goñi FM, Koning GA, Contreras FX

  Biochim Biophys Acta Biomembranes 1850:1656-70 (2015)

• Type I phosphatidylinositol 4-phosphate 5-kinase homo- and heterodimerization determines its membrane localization and activity

  Lacalle RA, de Karam JC, Martínez-Munoz L, Artetxe I, Peregil RM, Sot J, Rojas AM, Goñi FM, Mellado M, Manes S

  Faseb J. 29:2371-85 (2015)

• End-product diacylglycerol enhances the activity of PI-PLC through changes in membrane domain structure

  Ahyayauch H, Sot J, Collado MI, Huarte N, Requejo-Isidro J, Alonso A, Goni FM

  Biophys J. 108:1672-82 (2015)

• Atomic force microscopy characterization of palmitoylceramide and cholesterol effects on phospholipid bilayers: a topographic and nanomechanical study

  A.B. García-Arribas, J.V. Busto, A. Alonso and F.M. Goñi

  Langmuir 31, 3135-3145 (2015)

• Fluorescent polyene ceramide analogues as membrane probes

  Nieves I, Artetxe I, Abad JL, Alonso A, Busto JV, Fajarí L, Montes LR, Sot J, Delgado A, Goñi FM.

  Langmuir. 2015 Mar 3;31(8):2484-92

• Low pH modulates the macroorganization and thermal stability of PSII supercomplexes in grana membranes

  S. Stoichev, S.B. Krumova, T. Andreeva, J.V. Busto, S. Todinova, K. Balashev, M. Busheva, F.M. Goñi, and S.G. Taneva.

  Biophys. J. 108, 844–853 (2015)

• Histones cause aggregation and fusion of lipid vesicles containing phosphatidylinositol-4-phosphate

  Lete MG, Sot J, Gil D, Valle M, Medina M, Goñi FM, Alonso A

  Biophys J. 2015 Feb 17;108(4):863-71

• Two-Photon Laurdan Studies of the Ternary Lipid Mixture DOPC:SM:Cholesterol Reveal a Single Liquid Phase at Sphingomyelin:Cholesterol Ratios Lower Than 1

  P. Carravilla, J.L. Nieva, F.M. Goñi, J. Requejo-Isidro and N. Huarte

  Langmuir. 31(9):2808-17 (2015)

• Dipeptidyl peptidase-IV inhibitors used in type-2 diabetes inhibit a phospholipase C: a case of promiscuous scaffolds in proteins

  S. Chakraborty, A. Rendón-Ramírez, B. Ásgeirsson, M. Dutta, A.S. Ghosh, M. Oda, R. Venkatramani, B.J. Rao, A.M. Dandekar and F.M. Goñi.

  F1000 Res. doi: 10.12688/f1000research.2-286.v1 (2015).

• Solvation and hydration of the ceramide headgroup in a non-polar solution.

  R..J. Gillams, J.V. Busto, S. Busch, F.M. Goñi, C.D. Lorenz and S.E. McLain.

  J. Phys. Chem. B 119, 128−139. (2015).

• Interaction of Clostridium perfringens epsilon-toxin with biological and model membranes: A putative protein receptor in cells.

  M.M. Manni, J. Sot and F.M. Goñi.

  Biochim. Biophys. Acta 1848, 797–804 (2015).

• High-melting lipid mixtures and the origin of detergent-resistant membranes studied with temperature-solubilization diagrams.

  J. Sot, M.M. Manni, A.R. Viguera, V. Castañeda, A. Cano, C. Alonso, D. Gil, M. Valle, A. Alonso and F.M. Goñi.

  Biophys J. 107, 2828-2837 (2014).

• Biophysical properties of novel 1-deoxy-(dihydro)ceramides occurring in mammalian cells.

  N. Jiménez-Rojo, J. Sot, J.V. Busto, W.A. Shaw, J. Duan, A.H. Merrill, Jr., A. Alonso and F.M. Goñi.

  Biophys. J. 107, 2850-2859 (2014).

• Ether-versus ester-linked phospholipid bilayers containing either linear or branched apolar chains.

  D. Balleza, A.B. Garcia-Arribas, J. Sot, K. Ruiz-Mirazo and F.M. Goñi.

  Biophys J. 107, 1364-1374 (2014).

• A cholesterol recognition motif in human phospholipid Scramblase 1.

  I.M.D. Posada, J. Fantini, F.X. Contreras, F. Barrantes, A. Alonso and F.M. Goñi.

  Biophys J. 107, 1383-1392 (2014).

• Sphingosine induces the aggregation of imine-containing peroxidized vesicles.

  N. Jiménez-Rojo, A.R. Viguera, M.I. Collado, K.H. Sims, C. Constance, K. Hill, W.A. Shaw, F.M. Goñi and A. Alonso.

  Biochim. Biophys. Acta 1838, 2071-2077 (2014).

• N-Nervonoylsphingomyelin (C24:1) prevents lateral heterogeneity in cholesterol-containing membranes.

  S. Maté, J.V. Busto, A. García-Arribas, J. Sot, R. Vázquez, V. Herlax, C. Wolf, L. Bakás and F.M. Goñi.

  Biophys. J. 106 2606–2616 (2014).

• Membrane permeabilization induced by sphingosine: effect of negatively charged lipids.

  N. Jiménez-Rojo, J. Sot, A.R. Viguera, M.I. Collado, A. Torrecillas, J.C. Gómez-Fernández, F.M. Goñi and A. Alonso.

  Biophys. J. 106 2577–2584 (2014).

• The basic structure and dynamics of cell membranes: An update of the Singer-Nicolson model.

  F.M. Goñi.

  Biochim. Biophys. Acta 1838, 1467-1476 (2014).

• Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer\'s disease.

  M. Torres, S.L. Price, M.A. Fiol-deRoque, A. Marcilla-Etxenike, H. Ahyayauch, G. Barceló-Coblijn, S. Terés, L. Katsouri, M. Ordinas, D.J. López, M. Ibarguren, F.M. Goñi, X. Busquets, J. Vitorica, M. Sastre and P.V. Escribá.

  Biochim. Biophys. Acta 1838, 1680-1692 (2014).

• Biophysical properties of sphingosine, ceramides and other simple sphingolipids.

  F.M. Goñi, J. Sot and A. Alonso.

  Biochem Soc Trans. 42, 1401-1408 (2014).

• Membrane binding of human phospholipid scramblase 1 cytoplasmic domain.

  I.M. Posada, L. Sánchez-Magraner, J.H. Hervás, A. Alonso, H.L. Monaco and F.M. Goñi.

  Biochim. Biophys. Acta 1838, 1785-1792 (2014).

• Histones and DNA compete for binding polyphosphoinositides in bilayers.

  M.G. Lete, J. Sot, H. Ahyayauch, N. Fernández-Rivero, A. Prado, F.M. Goñi and A. Alonso.

  Biophys. J. 106, 1092–1100 (2014).

• Changes in membrane organization upon spontaneous insertion of 2-hydroxylated unsaturated fatty acids in the lipid bilayer.

  A. Khmelinskaia, M. Ibarguren, R.F.M. de Almeida, D.J. López, V.A. Paixa, H. Ahyayauch, F.M. Goñi and P.V. Escribá.

  Langmuir 30, 2117-2128 (2014).

• Lamellar gel (Lβ) phases of ternary lipid composition containing ceramide and cholesterol.

  J.V. Busto, A.B. García-Arribas, J. Sot, A. Torrecillas, J.C. Gómez-Fernández, F.M. Goñi and A. Alonso.

  Biophys. J. 106, 621-630 (2014).

• The C-terminal transmembrane domain of human phospholipid scramblase 1 is essential for the protein flip-flop activity and Ca2+-binding.

  L. Sánchez-Magraner, I.M. Posada, N. Andraka, F.X. Contreras, A.R. Viguera, D.M. Guérin, J.L.R. Arrondo, H.L. Monaco and F.M. Goñi.

  J Membr Biol. 247, 155-165 (2014).

• Membrane binding and insertion of the predicted transmembrane domain of human scramblase 1.

  I.M.D. Posada, J.V. Busto, F.M. Goñi and A. Alonso.

  Biochim. Biophys. Acta 1838, 388–397 (2014).

• Subcellular location of the coupling protein TrwB and the role of its transmembrane domain.

  R.L. Segura, S. Águila-Arcos, A.J. Vecino, F. de la Cruz, F.M. Goñi, and I. Alkorta.

  Biochim. Biophys. Acta. 1838, 223-230 (2014).

• Lipid bilayers containing sphingomyelins and ceramides of varying N-acyl lengths: A glimpse into sphingolipid complexity.

  N. Jiménez-Rojo, A.B. García-Arribas, J. Sot, A. Alonso and F.M. Goñi.

  Biochim. Biophys. Acta 1838, 456–464 (2014).

• Sobre la necesidad de una reforma universitaria.

  J.A. de Azcárraga and F.M. Goñi.

  Revista Española de Pedagogía 257, 5-22 (2014).

• Double-tailed lipid modification as a promising candidate for oligonucleotide delivery in mammalian cells.

  B. Ugarte-Uribe, S. Grijalvo, J.V. Busto, C. Martín, R. Eritja, F.M. Goñi, and I. Alkorta

  Biochim. Biophys. Acta General Subjects 1830: 4872-4884 (2013).

• Membrane partitioning of the pore-forming domain of Colicin A. role of the hydrophobic helical hairpin.

  I.L. Bermejo, C. Arnulphi, A. Ibáñez de Opakua, M. Alonso-Mariño, F.M. Goñi and A.R. Viguera.

  Biophys. J. 105, 1432-1443 (2013).

• The transmembrane domain of the T4SS coupling protein TrwB and its role in protein-protein interactions.

  R.L. Segura, S. Aguila-Arcos, B. Ugarte-Uribe, A.J. Vecino,F. de la Cruz, F.M. Goñi and I. Alkorta.

  Biochim Biophys Acta, 1828, 2015-2025 (2013).

• A computational module assembled from different protease family motifs identifies PI PLC from Bacillus cereus as a putative prolyl peptidase with a serine protease scaffold.

  A. Rendón-Ramírez, M. Shukia, M. Oda, S. Chakraborty, R. Minda, A.M. Dandekar, B. Ásgeirsson, F.M. Goñi and B. J. Rao.

  PLoS One, 8(8):e70923. doi: 10.1371/journal.pone.0070923 (2013).

• The mechanism of detergent solubilization of lipid bilayers.

  D. Lichtenberg, H. Ahyayauch and F.M. Goñi.

  Biophys. J. 105, 289–299 (2013).

• Effects of chronic and acute lead treatments on the biophysical properties of erythro- cyte membranes, and a comparison with model membranes.

  H. Ahyayauch, W. Sansar, A. Rendón-Ramírez, F.M. Goñi, M. Bennouna and H. Gamrani.

  FEBS Open Bio 3, 212–217 (2013).

• Dipeptidyl peptidase-IV inhibitors used in type-2 diabetes inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.

  S. Chakraborty, A. Rendón-Ramírez, B. Ásgeirsson, M. Dutta, A.S. Ghosh, M. Oda, R. Venkatramani, B.J. Rao, A.M. Dandekar and F.M. Goñi.

  F1000 Res. doi: 10.12688/f1000research.2-286.v1 (2013).

• The onset of Triton X-100 solubilization of sphingomyelin/ceramide bilayers: effects of temperature and composition.

  H. Ahyayauch, C. Arnulphi, J. Sot, A. Alonso and F.M. Goñi.

  Chem. Phys. Lipids. 167-168, 57-61 (2013).

• Detergent solubilization of lipid bilayers: a balance of driving forces.

  D. Lichtenberg, H. Ahyayauch, A. Alonso and F.M. Goñi.

  Trends Biochem Sci. 38, 85-93 (2013).

• A biophysicist in the kitchen.

  F.M. Goñi

  Flavour, 2:7 (2013).

• Recruitment of a phospholipase C/sphingomyelinase into non-lamellar lipid droplets during hydrolysis of lipid bilayers.

  M. Ibarguren, J. Sot, L.R. Montes, A.I. Vasil, M.L. Vasil, F.M. Goñi and A. Alonso.

  Chem Phys Lipids. 166, 12-17 (2013).

• Insights into sphingolipid miscibility: separate observation of sphingomyelin and ceramide N-acyl chain melting.

  S.S.W. Leung, J.V. Busto, A. Keyvanloo, F.M. Goñi and J. Thewalt.

  Biophys J. 103, 2465-2474 (2012).

• Deletion of a single helix from the transmembrane domain causes large changes in membrane insertion properties and secondary structure of the bacterial conjugation protein TrwB

  A.J. Vecino, R. de L. Segura, I. de la Arada, F. de la Cruz, F.M. Goñi, J.L. Arrondo and I. Alkorta.

  Biochim Biophys Acta. 1818, 3158-3166 (2012).

• Binding of b-Amyloid (1–42) peptide to negatively charged phospholipid membranes in the liquid-ordered state: modeling and experimental studies.

  H. Ahyayauch, M. Raab, J.V. Busto, N. Andraka, J.L. R. Arrondo, M. Masserini, I. Tvaroska and F.M. Goñi.

  Biophys. J. 103, 453–463 (2012).

• Lipid bilayers in the gel phase become saturated by Triton X-100 at lower surfactant concentrations than those in the fluid phase.

  H. Ahyayauch, M.I. Collado, A. Alonso and F.M. Goñi.

  Biophys. J. 102 1–7 (2012).

• Phospholipases C and sphingomyelinases: Lipids as substrates and modulators of enzyme activity.

  F.M. Goñi, L.R. Montes and A. Alonso.

  Prog Lipid Res 51, 238–266 (2012).

• Accumulated bending energy elicits neutral sphingomyelinase activity in human red blood cells.

  D.J. López, M. Egido-Gabas, I. López-Montero, J.V. Busto, J. Casas, M. Garnier, F. Monroy, B. Larijani, F.M. Goñi and A. Alonso.

  Biophys. J. 102 2077–2085 (2012).

• Model systems of precursor cellular membranes: long-chain alcohols stabilize spontaneously formed oleic acid vesicles.

  A. Rendón, D. Gil Carton, J. Sot, M. García-Pacios, L.R. Montes, M. Valle, J.L.R. Arrondo, F.M. Goñi and K. Ruiz-Mirazo

  Biophys. J. 102, 278–286 (2012).

• Membrane insertion stabilizes the structure of TrwB, the R388 conjugative plasmid coupling protein.

  A.J. Vecino, I. de la Arada, R.L. Segura, F.M. Goñi, F. de Cruz, J.L. R. Arrondo and I. Alkorta.

  Biochim. Biophys. Acta 1808, 1032-1039 (2011).