
Phone. +34-94.601.3354
Alicia Alonso
Professor (UPV/EHU)
Born in Bilbao- Received her M.Sc .in Biology at the University of Bilbao, where she then worked for her Ph .D. in Biochemistry. in 1980 Her thesis and a large part of her further research has dealt with the interactions of cell and model membranes with detergents and the role of lipids in membrane fusion. She worked as a post-doctoral scientist with Dennis Chapman, at the Royal Free Hospital, London. She has been a Lecturer and, since 1992, a Professor of Biochemistry at the University of the Basque Country, in Bilbao. In 1998 she was the first Head of the newly created Unidad de Biofísica, a joint center of the Spanish National Research Center (CSIC) and the University of the Basque Country, where she works now. In 1999-2000 she was a Visiting Professor at the University of Victoria (British Columbia, Canada). She has been President of the Spanish Biophysical Society (2006-2010), Vice-President of the Spanish Society for Biochemistry and Molecular Biology (2010-2014) and a Member of the Council of the International Union for Pure and Applied Biophysics, IUPAB (2008-2014). She is the author or co-author of around 150 scientific publications on various aspects of membrane biophysics.
Publications
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The interaction of Aβ42 peptide in monomer, oligomer or fibril forms with sphingomyelin/cholesterol/ganglioside bilayers
Ahyayauch H, Masserini M, Goñi FM, Alonso A.
Int J Biol Macromol. S0141-8130(20)35037-6. doi: 10.1016/j.ijbiomac.2020.11.112. (2021)
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Phase-selective staining of model and cell membranes, lipid droplets and lipoproteins with fluorescent solvatochromic pyrene probes
Sot J, Esnal I, Monasterio BG, León-Irra R, Niko Y, Goñi FM, Klymchenko A, Alonso A.
Biochim Biophys Acta Biomembr. 1863(1):183470. (2021) doi: 10.1016/j.bbamem.2020.183470. (2021)
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β-Amyloid (1-42) peptide adsorbs but does not insert into ganglioside-containing phospholipid membranes in the liquid-disordered state: modelling and experimental studies
Ahyayauch H, García-Arribas AB, Masserini ME, Pantano S, Goñi FM, Alonso A.
Int J Biol Macromol. 164:2651-2658. (2020) doi: 10.1016/j.ijbiomac.2020.08.165. (2020)
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Exploring polar headgroup interactions between sphingomyelin and ceramide with infrared spectroscopy
de la Arada I, González-Ramírez EJ, Alonso A, Goñi FM, Arrondo JR.
Sci Rep. 10(1):17606. (2020) doi: 10.1038/s41598-020-74781-8. (2020)
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C24:0 and C24:1 sphingolipids in cholesterol-containing, five- and six-component lipid membranes
González-Ramírez EJ, García-Arribas AB, Sot J, Goñi FM, Alonso A.
Sci Rep. 10(1):14085. (2020) doi: 10.1038/s41598-020-71008-8. (2020)
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Patches and Blebs: A Comparative Study of the Composition and Biophysical Properties of Two Plasma Membrane Preparations from CHO Cells
Monasterio BG, Jiménez-Rojo N, García-Arribas AB, Riezman H, Goñi FM, Alonso A.
Int J Mol Sci. 21(7). pii: E2643. (2020) doi: 10.3390/ijms21072643. (2020)
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The Binding of Aβ42 Peptide Monomers to Sphingomyelin/Cholesterol/Ganglioside Bilayers Assayed by Density Gradient Ultracentrifugation
Ahyayauch H, de la Arada I, Masserini ME, Arrondo JLR, Goñi FM, Alonso A.
Int J Mol Sci. 21(5). pii: E1674. (2020) doi: 10.3390/ijms21051674. (2020)
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Mixing brain cerebrosides with brain ceramides, cholesterol and phospholipids
González-Ramírez EJ, Goñi FM, Alonso A.
Sci Rep. 9(1):13326. (2019) doi: 10.1038/s41598-019-50020-7. (2019)
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Fast and slow biomembrane solubilizing detergents: Insights into their mechanism of action
Lete MG, Monasterio BG, Collado MI, Medina M, Sot J, Alonso A, Goñi FM.
Colloids Surf B Biointerfaces. ;183:110430. (2019) doi: 10.1016/j.colsurfb.2019.110430. (2019)
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Lamellar Phases Composed of Phospholipid, Cholesterol, and Ceramide, as Studied by 2H NMR
Siavashi R, Phaterpekar T, Leung SSW, Alonso A, Goñi FM, Thewalt JL.
Biophys J. pii: S0006-3495(19)30497-7. doi: 10.1016/j.bpj.2019.05.027. [Epub ahead of print] (2019)
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Homogeneous and Heterogeneous Bilayers of Ternary Lipid Compositions Containing Equimolar Ceramide and Cholesterol
González-Ramírez EJ, Artetxe I, García-Arribas AB, Goñi FM, Alonso A.
Langmuir 35(15):5305-5315. doi: 10.1021/acs.langmuir.9b00324 (2019)
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The interaction of lipid-liganded gold clusters (Aurora ™) with lipid bilayers
J Sot J, SA Mendanha-Neto SA, JV Busto JV, AB García-Arribas, S Li, SW Burgess, WA Shaw, D Gil-Carton, FM Goñi, A Alonso.
Chem Phys Lipids. 218:40-46. doi: 10.1016/j.chemphyslip.2018.11.007 (2019)
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Biophysical Studies of LC3 Family Proteins
Hervás JH, Antón Z, Alonso A
Methods Mol Biol. 1880:91-117. doi: 10.1007/978-1-4939-8873-0_5 (2019)
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The fatty acids of sphingomyelins and ceramides in mammalian tissues and cultured cells: Biophysical and physiological implications
MM Manni, J Sot, E Arretxe, R Gil-Redondo, JM Falcón-Pérez, D Balgoma, C Alonso, FM Goñi, A Alonso.
Chem Phys Lipids. 217:29-34. doi:10.1016/j.chemphyslip.2018.09.010 (2018)
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Omega-3 polyunsaturated fatty acids do not fluidify bilayers in the liquid-crystalline state
A De Santis, Y Varela, J Sot, G D\'Errico, FM Goñi, A Alonso.
Sci Rep. 8(1):16240. doi: 10.1038/s41598-018-34264-3 (2018)
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Clearly Detectable, Kinetically Restricted Solid−Solid Phase Transition in cis-Ceramide Monolayers
Fanani ML, Busto JV, Sot J, Abad JL, Fabrías G, Saiz L, Vilar JMG, Goñi FM, Maggio B, Alonso A.
Langmuir; 34(39):11749-11758. doi: 10.1021/acs.langmuir.8b02198. (2018)
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Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells
Ahyayauch H, García-Arribas AB, Sot J, González-Ramírez EJ, Busto JV, Monasterio BG, Jiménez-Rojo N, Contreras FX, Rendón-Ramírez A, Martin C, Alonso A, Goñi FM.
Sci Rep. 8, 7456. doi: 10.1038/s41598-018-25905-8 (2018)
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The Physical Properties of Ceramides in Membranes
Alonso A, Goñi FM.
Annu Rev Biophys. 2018. doi: 10.1146/annurev-biophys-070317-033309 (2018)
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Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge
J.H. Hervas, A. Landajuela, Z. Anton, A.V. Shnyrova, F.M. Goni and A. Alonso
Sci Rep 7, 15614 doi: 10.1038/s41598-017-15057-6 (2017)
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Complex Effects of 24:1 Sphingolipids in Membranes Containing Dioleoylphosphatidylcholine and Cholesterol
A.B. Garcia-Arribas, E.J. Gonzalez-Ramirez, J. Sot, I. Areso, A. Alonso and F.M. Goni
Langmuir 33, 5545-5554 doi: 10.1021/acs.langmuir.7b00162 (2017)
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Vesicular PtdIns(3,4,5) P-3 and Rab7 are key effectors of sea urchin zygote nuclear membrane fusión
M.G. Lete, R.D. Byrne, A. Alonso, D. Poccia and B. Larijani
J Cell Sci 130, 444-452 doi: 10.1242/jcs.193771 (2017)
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Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP
Z. Anton, A. Landajuela, J.H. Hervas, L.R. Montes, S. Hernandez-Tiedra, G. Velasco, F.M Goñi and A. Alonso
Autophagy. 12, 2386-2403 (2016)
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Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
S. Hernández-Tiedra, G. Fabriàs, D. Dávila, I.J. Salanueva, J. Casas, L.R. Montes, Z. Antón, E. García-Taboada, M. Salazar-Roa, M. Lorente, J. Nylandsted, J. Armstrong, I. López-Valero, C.S. McKee, A. Serrano-Puebla, R. García-López, J. González-Martínez, J.L. Abad, K. Hanada, P. Boya, F.M. Goñi, M. Guzmán, P. Lovat, M. Jäättelä, A. Alonso and G. Velasco
Autophagy. 12, 2213-2229. (2016)
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Cholesterol interactions with ceramide and sphingomyerlin
A.B. García-Arribas, A. Alonso and F.M. Goñi
Chem Phys Lipids. 199, 26-34 (2016)
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Ceramide-induced lamellar gel phases in fluid cell lipid extracts
A.B. Garcia-Arribas, H. Ahyayauch, J. Sot, P.L. Lopez-Gonzalez, A. Alonso and F.M. Goñi
Langmuir 32, 9053-9063 (2016)
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Cholesterol-ceramide interactions in phospholipid and sphingolipid bilayers as observed by positron annihilation lifetime spectroscopy and molecular dynamics simulations
A.B. García Arribas, R. Axpe, J.I. Mujika, D. Mérida, J.V. Busto, J. Sot, A. Alonso, X. Lopez, J.A. García, J.M. Ugalde, F. Plazaola and F.M. Goñi
Langmuir. 32, 5434-5444 (2016)
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Thermotropic properties of ceramides in aqueous or lipidic environments
A. Alonso and F.M. Goñi
Book article CRC Press, Boca Raton, FL, USA, pp. 137-151 (2016)
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Lipid geometry and bilayer curvature modulate LC3/GABARAP-mediated model autophagosomal elongation
A. Landajuela, J.H. Hervas, Z. Anton, L.R. Montes, D. Gil, M. Valle, J.F. Rodriguez, F. M. Goñi and A. Alonso
Biophys J. 110, 411–422 (2016)
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Thermally-induced aggregation and fusion of protein-free lipid vesicles
Ibarguren M, Bomans Ph, Ruiz-Mirazo K, Frederik PM, Alonso A, Goñi FM
Colloid Surface B. 136:545-52 (2015)
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Solid lipid nanoparticles for delivery of Calendula officinalis extract
Arana L, Salado C, Vega S, Aizpurua-Olaizola O, Arada I, Suarez T, Usobiaga A, Arrondo JL, Alonso A, Goni FM, Alkorta I
Colloid Surface B. 135:18-26 (2015)
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Lipidic nanovesicles stabilize suspensions of metal oxide nanoparticles
Jimenez-Rojo N, Lete MG, Rojas E, Gil D, Valle M, Alonso A, Moya SE, Goñi FM
Chem Phys Lipids. 191:84-90 (2015)
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Endomembrane PtdIns(3,4,5)P3 activates the PI3K/Akt pathway
Jethwa N, Chung GH, Lete MG, Alonso A, Byrne Rd, Calleja V, Larijani B
J Cell Sci. 128:3456-65 (2015)
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End-product diacylglycerol enhances the activity of PI-PLC through changes in membrane domain structure
Ahyayauch H, Sot J, Collado MI, Huarte N, Requejo-Isidro J, Alonso A, Goni FM
Biophys J. 108:1672-82 (2015)
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Atomic force microscopy characterization of palmitoylceramide and cholesterol effects on phospholipid bilayers: a topographic and nanomechanical study
A.B. García-Arribas, J.V. Busto, A. Alonso and F.M. Goñi
Langmuir 31, 3135-3145 (2015)
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Fluorescent polyene ceramide analogues as membrane probes
Nieves I, Artetxe I, Abad JL, Alonso A, Busto JV, Fajarí L, Montes LR, Sot J, Delgado A, Goñi FM.
Langmuir. 2015 Mar 3;31(8):2484-92
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Histones cause aggregation and fusion of lipid vesicles containing phosphatidylinositol-4-phosphate
Lete MG, Sot J, Gil D, Valle M, Medina M, Goñi FM, Alonso A
Biophys J. 2015 Feb 17;108(4):863-71
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Biophysical properties of novel 1-deoxy-(dihydro)ceramides occurring in mammalian cells.
N. Jiménez-Rojo, J. Sot, J.V. Busto, W.A. Shaw, J. Duan, A.H. Merrill, Jr., A. Alonso and F.M. Goñi.
Biophys. J. 107, 2850-2859 (2014).
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High-melting lipid mixtures and the origin of detergent-resistant membranes studied with temperature-solubilization diagrams.
J. Sot, M.M. Manni, A.R. Viguera, V. Castañeda, A. Cano, C. Alonso, D. Gil, M. Valle, A. Alonso and F.M. Goñi.
Biophys J. 107, 2828-2837 (2014).
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A cholesterol recognition motif in human phospholipid Scramblase 1.
I.M.D. Posada, J. Fantini, F.X. Contreras, F. Barrantes, A. Alonso and F.M. Goñi.
Biophys J. 107, 1383-1392 (2014).
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Sphingosine induces the aggregation of imine-containing peroxidized vesicles.
N. Jiménez-Rojo, A.R. Viguera, M.I. Collado, K.H. Sims, C. Constance, K. Hill, W.A. Shaw, F.M. Goñi and A. Alonso.
Biochim. Biophys. Acta 1838, 2071-2077 (2014).
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Membrane permeabilization induced by sphingosine: effect of negatively charged lipids.
N. Jiménez-Rojo, J. Sot, A.R. Viguera, M.I. Collado, A. Torrecillas, J.C. Gómez-Fernández, F.M. Goñi and A. Alonso.
Biophys. J. 106 2577–2584 (2014).
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Biophysical properties of sphingosine, ceramides and other simple sphingolipids.
F.M. Goñi, J. Sot and A. Alonso.
Biochem Soc Trans. 42, 1401-1408 (2014).
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Membrane binding of human phospholipid scramblase 1 cytoplasmic domain.
I.M. Posada, L. Sánchez-Magraner, J.H. Hervás, A. Alonso, H.L. Monaco and F.M. Goñi.
Biochim. Biophys. Acta 1838, 1785-1792 (2014).
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Histones and DNA compete for binding polyphosphoinositides in bilayers.
M.G. Lete, J. Sot, H. Ahyayauch, N. Fernández-Rivero, A. Prado, F.M. Goñi and A. Alonso.
Biophys. J. 106, 1092–1100 (2014).
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Lamellar gel (Lβ) phases of ternary lipid composition containing ceramide and cholesterol.
J.V. Busto, A.B. García-Arribas, J. Sot, A. Torrecillas, J.C. Gómez-Fernández, F.M. Goñi and A. Alonso.
Biophys. J. 106, 621-630 (2014).
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Membrane binding and insertion of the predicted transmembrane domain of human scramblase 1.
I.M.D. Posada, J.V. Busto, F.M. Goñi and A. Alonso.
Biochim. Biophys. Acta 1838, 388–397 (2014).
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Lipid bilayers containing sphingomyelins and ceramides of varying N-acyl lengths: A glimpse into sphingolipid complexity.
N. Jiménez-Rojo, A.B. García-Arribas, J. Sot, A. Alonso and F.M. Goñi.
Biochim. Biophys. Acta 1838, 456–464 (2014).
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The onset of Triton X-100 solubilization of sphingomyelin/ceramide bilayers: effects of temperature and composition.
H. Ahyayauch, C. Arnulphi, J. Sot, A. Alonso and F.M. Goñi.
Chem. Phys. Lipids. 167-168, 57-61 (2013).
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Detergent solubilization of lipid bilayers: a balance of driving forces.
D. Lichtenberg, H. Ahyayauch, A. Alonso and F.M. Goñi.
Trends Biochem Sci. 38, 85-93 (2013).
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Recruitment of a phospholipase C/sphingomyelinase into non-lamellar lipid droplets during hydrolysis of lipid bilayers.
M. Ibarguren, J. Sot, L.R. Montes, A.I. Vasil, M.L. Vasil, F.M. Goñi and A. Alonso.
Chem Phys Lipids. 166, 12-17 (2013).
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Lipid bilayers in the gel phase become saturated by Triton X-100 at lower surfactant concentrations than those in the fluid phase.
H. Ahyayauch, M.I. Collado, A. Alonso and F.M. Goñi.
Biophys. J. 102 1–7 (2012).
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Phospholipases C and sphingomyelinases: Lipids as substrates and modulators of enzyme activity.
F.M. Goñi, L.R. Montes and A. Alonso.
Prog Lipid Res 51, 238–266 (2012).
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Accumulated bending energy elicits neutral sphingomyelinase activity in human red blood cells.
D.J. López, M. Egido-Gabas, I. López-Montero, J.V. Busto, J. Casas, M. Garnier, F. Monroy, B. Larijani, F.M. Goñi and A. Alonso.
Biophys. J. 102 2077–2085 (2012).