Protein Folding and Chaperones

Group leader
Fernando Moro Pérez
Phone
+34 946 01 8013
Address

Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

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Research goal

Living systems host a crowd of molecular chaperones that act with different mechanisms and serve to maintain protein homeostasis. Our group studies nuclear and cytosolic chaperones. Among the cytosolic chaperones we are interested in members of the Hsp60, Hsp70 and Hsp100 families.

Group members
University Lecturer / Vicedirector of Infrastructure and Equipment
Publications

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Santos J, Cuellar J, Pallarès I, Byrd EJ, Lends A, Moro F, Abdul-Shukkoor MB, Pujols J, Velasco-Carneros L, Sobott F, Otzen DE, Calabrese AN, Muga A, Pedersen JS, Loquet A, Valpuesta JM, Radford SE, Ventura S

A Targetable N-Terminal Motif Orchestrates α-Synuclein Oligomer-to-Fibril Conversion
J Am Chem Soc. 2024 May 8;146(18):12702-12711
doi: 10.1021/jacs.4c02262

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Velasco-Carneros L, Cuéllar J, Dublang L, Santiago C, Maréchal JD, Martín-Benito J, Maestro M, Fernández-Higuero JÁ, Orozco N, Moro F, Valpuesta JM, Muga A.

The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70
Nat Commun. 2023 Sep 5;14(1):5436
DOI: 10.1038/s41467-023-41150-8

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Morten MJ, Sirvio L, Rupawala H, Mee Hayes E, Franco A, Radulescu C, Ying L, Barnes SJ, Muga A, Ye Y.

Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies
Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2205591119
DOI: 10.1073/pnas.2205591119

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Cabrera Y, Bernardo-Seisdedos G, Dublang L, Albesa-Jové D, Orozco N, Viguera AR, Millet O, Muga A, Moro F.

Fine-tuning of the Hsc70-based Human Protein Disaggregase Machinery by the Distinctive C-terminal Extension of Apg2
J Mol Biol. 2022 Nov 30;434(22):167841
DOI: 10.1016/j.jmb.2022.167841

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Franco A, Cuéllar J, Fernández-Higuero JÁ, de la Arada I, Orozco N, Valpuesta JM, Prado A, Muga A.

Truncation-Driven Lateral Association of α-Synuclein Hinders Amyloid Clearance by the Hsp70-Based Disaggregase
Int J Mol Sci. 2021 Nov 30;22(23):12983
DOI: 10.3390/ijms222312983

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Franco A, Velasco-Carneros L, Alvarez N, Orozco N, Moro F, Prado A, Muga A.

Unzipping the Secrets of Amyloid Disassembly by the Human Disaggregase
Cells. 2021 Oct 14;10(10):2745
DOI: 10.3390/cells10102745

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Franco A, Gracia P, Colom A, Camino JD, Fernández-Higuero JÁ, Orozco N, Dulebo A, Saiz L, Cremades N, Vilar JMG, Prado A, Muga A.

All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species
Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2105548118
DOI: 10.1073/pnas.2105548118