Biophysics of Morphogenesis

Group leader
Jérôme Solon
Phone
+34 946 01 5134
Address

Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

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Research goal

Our group is interested in understanding the mechanisms at the origin of force generation, coordination and regulation in biological tissues during animal development. Our group uses an interdisciplinary approach, combining expertise in Drosophila genetics and molecular biology with high-resolution live imaging, biophysical analysis and modelling, with the aim of building a quantitative description of the mechano-chemical properties of the morphogenetic processes occurring during Drosophila Melanogaster embryogenesis.

Group members
Postdoctoral Fellow
Investigo Research Assistant
PhD Student
Research Technician
Marie Sklodowska-Curie Postdoctoral Fellow
Distinguished University Researcher / Ikerbasque Research Professor
PhD Student
Publications

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Kozak EL, Miranda-Rodríguez JR, Borges A, Dierkes K, Mineo A, Pinto-Teixeira F, Viader-Llargués O, Solon J, Chara O, López-Schier H
Quantitative videomicroscopy reveals latent control of cell-pair rotations in vivo
Development. 2023 May 1;150(9):dev200975
doi: 10.1242/dev.200975

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Rogalla S, Bengoetxea G, Solon J
Shaping the heart with mechanosensitive shrinking cells
Dev Cell. 2022 Mar 14;57(5):566-568
doi: 10.1016/j.devcel.2022.02.016

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Fraire-Zamora JJ, Tosi S, Solon J, Casanova J
Control of hormone-driven organ disassembly by ECM remodeling and Yorkie-dependent apoptosis
Curr Biol. 2021 Dec 6;31(23):5261-5273.e4
doi: 10.1016/j.cub.2021.09.057

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Trubuil É, Solon J
A Compression Engine to Coordinate Tissue Elongation in the Embryo
Dev Cell. 2020 Nov 9;55(3):256-258
doi: 10.1016/j.devcel.2020.10.013

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D’Angelo A, Dierkes K., Carolis C., Salbreux G., Solon J.

In vivo force application reveals a fast tissue softening and external friction increase during early embryogenesis.
Curr Biol. 2019 May 6;29(9):1564-1571.
DOI: 10.1016/j.cub.2019.04.010

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D’Angelo A., Godeau A.L., Solon J.

A new player in tissue mechanics: MicroRNA control of mechanical homeostasis.
Dev Cell. 2019 Mar 11;48(5):596-598.
DOI: 10.1016/j.devcel.2019.02.019

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Sumi A., Hayes P., D’Angelo A., Colombelli J., Salbreux G., Dierkes K., Solon J.

Adherens junction length during tissue contraction is controlled by the mechanosensitive activity of actomyosin and junctional recycling.
Dev Cell. 2018 Nov 19;47(4):453-463.
DOI: 10.1016/j.devcel.2018.10.025

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Agmon E., Solon J., Bassereau P., Stockwell B.R.

Modeling the effects of lipid peroxidation during ferroptosis on membrane properties
Sci Rep. 2018 Mar 26;8(1):5155.
DOI: 10.1038/s41598-018-23408-0

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Fraire-Zamora J.J., Jaeger J., Solon J.

Two consecutive microtubule-based epithelial seaming events mediate dorsal closure in the scuttle fly Megaselia abdita.
Elife. 2018 Mar 14:7:e33807.
DOI: 10.7554/eLife.33807