| Biofisika

Access all the 2010-2011-2012 publications through the next link.

Public 2010-2012

Access all the publications since 2013 on (included) through the next links.

Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface

E. Rujas, J.M. Caaveiro, A. Partida-Hanon, N. Gulzar, K. Morante, B. Apellániz, M. García-Porras, M. Bruix, K. Tsumoto, J.K. Scott, M.A. Jiménez and J.L. Nieva.

Sci Rep. 6, 38177 doi.10.1038/srep38177 (2016)

A diet enriched with plant sterols prevents the memory impairment induced by cholesterol loss in senescence-accelerated mice

A. Perez-Cañamas, S. Sarroca, C. Melero-Jerez, D. Porquet, J. Sansa, S. Knafo, J.A. Esteban, C. Sanfeliu and M.D. Ledesma

Neurobiol Aging. 48, 1-12 (2016)

Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP

Z. Anton, A. Landajuela, J.H. Hervas, L.R. Montes, S. Hernandez-Tiedra, G. Velasco, F.M Goñi and A. Alonso

Autophagy. 12, 2386-2403 (2016)

A celular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K

I. García-Santisteban, I. Arregi, M. Alonso-Mariño, M.A. Urbaneja, J.J. Garcia-Vallejo, S. Bañuelos and J.A. Rodríguez

Cell Mol Life Sci. 73, 4685-4699 (2016)

Early-onset epileptic encephalopathy caused by a reduced sensitivity of Kv7.2 potassium channels to phosphatidylinositol 4,5-bisphosphate

M.V. Soldovieri, P. Ambrosino, I. Mosca, M. De Maria, E. Moreto, F. Miceli, A. Alaimo, N. Iraci, L. Manocchio, A. Medoro, M. Passafaro and M. Taglialatela

Sci Rep. 1; 6:38167. doi: 10.1038/srep38167 (2016)

The use of targeted exome sequencing in genetic diagnosis of young patients with severe hypercholesterolemia

L. Jiang, W.F.Wu, L.Y. Sun, P.P. Chen, W. Wang, A. Benito-Vicente, F. Zhang, X.D. Pan, W. Cui, S.W. Yang, Y.J. Zhou, C. Martin and L.Y. Wang

Sci Rep. 6, 36823 doi. 10.1038/srep36823 (2016)

Structural changes induced by acidic pH in human apolipoprotein B-100

J.A. Fernández-Higuero, A. Benito-Vicente, A. Etxebarria, J.C. Milicua, H. Ostolaza, J.L. Arrondo and C. Martín

Sci Rep. 6, 36324 doi: 10.1038/srep36324 (2016)

Membrane fission by dynamin: what we know and what we need to know

B. Antonny, C. Burd, P. De Camilli, E. Chen, O. Daumke, K. Faelber, M. Ford, V.A. Frolov, A. Frost, J.E. Hinshaw, T. Kirchhausen, M.M. Kozlov, M. Lenz, H.H. Low, H. McMahon, C. Merrifield, T.D. Pollard, P.J. Robinson, A. Roux and S. Schmid

EMBO J. 35, 2270-2284 (2016)

PCSK9 and lipoprotein (a) levels are two predictors of coronary artery calcification in asymptomatic patients with familial hypercholesterolemia

R. Alonso, P. Mata, O. Muñiz, F. Fuentes-Jimenez, J.L. Díaz, D. Zambón, M. Tomás, C. Martin, T. Moyon, M. Croyal, A. Thedrez and G. Lambert

Atherosclerosis. 254, 249-253 (2016)

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

S. Hernández-Tiedra, G. Fabriàs, D. Dávila, I.J. Salanueva, J. Casas, L.R. Montes, Z. Antón, E. García-Taboada, M. Salazar-Roa, M. Lorente, J. Nylandsted, J. Armstrong, I. López-Valero, C.S. McKee, A. Serrano-Puebla, R. García-López, J. González-Martínez, J.L. Abad, K. Hanada, P. Boya, F.M. Goñi, M. Guzmán, P. Lovat, M. Jäättelä, A. Alonso and G. Velasco

Autophagy. 12, 2213-2229. (2016)

Alteration of a second putative fusion peptide of structural glycoprotein E2 of classical swine fever virus alters virus replication and virulence in swine

L.G. Holinka, E. Largo, D.P. Glaude, V. O’Donnell, G.R. Risatti, J.L. Nieva and M.V. Borca

J.Virol. 90, 10299-10308 (2016)

X-ray structure of Triatoma virus empty capsid: insights into the mechanism of uncoating and RNA release in dicistroviruses

R. Sanchez Eugenia, A. Durana, I. Lopez-Marijuan, G.A. Marti and D.M. Guerin

J. Gen. Virol. 97, 2769-2779 (2016)

The conformational plasticity of glycosyltransferases

D. Albesa-Jove and M.E. Guerin

Curr Opin Struct Biol. 40, 23-32 (2016)

Synthesis, lipid membrane incorporation, and ion permeability testing of carbon nanotube porins

R.H. Tunuguntla, A. Escalada, V. Frolov and A. Noy

Nat Protoc. 11, 2029-2047 (2016)

Functional organizacion of the HIV lipid envelope

N. Huarte, P. Carravilla, A. Cruz, M. Lorizate, J.A. Nieto-Garai, H.G. Kräusslich, J. Perez-Gil, J.M. Requejo and J.L. Nieva

Sci Rep 6 34190. doi: 10.1038/srep34190 (2016)

Identification of a membrane-bound prepore species clarifies the lytic mechanism of actinoporins

K. Morante, A. Bellomio, D. Gil-Cartón, L. Redondo-Morata, J. Sot, S. Scheuring, M. Valle, J.M. González-Mañas, K. Tsumoto, and J.M.M. Caaveiro

J Biol Chem. 291, 19210-19219 (2016)

Structural basis of glycogen biosynthesis regulation in bacteria

J.O. Cifuente, N. Comino, J.Madariaga-Marcos, S. Lopez-Fernandez, M. Garcia-Alija, J. Aguirre, D. Albesa-Jové and M.E. Guerin

Structure 6, 1613-1622 (2016)

Ubiquitin-specific protease 36 (USP36) controls neuronal precursor cell-expressed developmentally down-regulated 4-2 (Nedd4-2) actions over the neurotrophin receptor TrkA and potassium voltage-gated channels 7.2/3 (Kv7.2/3)

B. Anta, C. Martín-Rodríguez, C. Gomis-Perez, L. Calvo, S. López-Benito, A.A. Calderón-García, C. Vicente-García, A. Villarroel and J.C. Arévalo

J Biol Chem. 291, 19132-19145 (2016)

Cholesterol interactions with ceramide and sphingomyerlin

A.B. García-Arribas, A. Alonso and F.M. Goñi

Chem Phys Lipids. 199, 26-34 (2016)

Administration of the TrkB receptor agonist 7,8-dihydroxyflavone prevents traumatic stress-induced spatial memory deficits and changes in synaptic plasticity

A. Sanz-Garcia, S. Knafo, I. Pereda-Perez, J.A. Esteban, C. Venero and A. Armario

Hippocampus. 26, 1179-1188 (2016)

A quantitative characterization of nucleoplasmin/histone complexes reveals chaperone versatility

N. Fernandez-Rivero, A. Franco, A, Velazquez-Campoy, E. Alonso, A. Muga and A. Prado

Sci Rep. 6, 32114 doi.10.1038/srep 32114 (2016)

Glycosylation-dependent IFN-γR partitioning in lipid and actin nanodomains is critical for JAK activation

C.M. Blouin, Y. Hamon, P. Gonnord, C. Boularan, J. Kagan, C. Viaris de Lesegno, R. Ruez, S. Mailfert, N. Bertaux , D. Loew, C. Wunder, L. Johannes, G. Vogt, FX. Contreras, D. Marguet, J.L. Casanova, C. Galès, H.T. He and C. Lamaze

Cell. 166, 920-934 (2016)

Ceramide-induced lamellar gel phases in fluid cell lipid extracts

A.B. Garcia-Arribas, H. Ahyayauch, J. Sot, P.L. Lopez-Gonzalez, A. Alonso and F.M. Goñi

Langmuir 32, 9053-9063 (2016)

TssA forms a gp6-like ring attached to the type VI secretion sheath

Planamente S, Salih O, Manoli E, Albesa-Jové D, Freemont PS, Filloux A

EMBO J. 35, 1613-27. (2016)

Molecular basis of membrane association by the phosphatidylinositol mannosyltransferase PimA enzyme from mycobacteria

A. Rodrigo-Unzueta, M.A. Martinez, N. Comino, P.M. Alzari, A Chenal and M.E Guerin.

J Biol Chem. 291, 13955-13963. (2016)

A crowdsourcing approach to developing and assessing prediction algorithms for AML prognosis

D.P. Noren, B.L. Long, R. Norel, K. Rrhissorrarrakrai, K. Hess, C.W. Hu, A.J. Bisberg, A. Schulz, E. Engquist, L. Liu, X. Lin, G.M. Chen, H. Xie, G.A.M. Hunter, P.C. Boutros, O. Stepanov, DREAM 9 AML-OPC Consortium, T. Norman, S.H. Friend, G. Stolovitzky, S. Kornblau and A.A. Qutub , Collaborator JM Vilar

PloS Comput Biol. 12:e1004890. doi: 10.1371/journal.pcbi.1004890 (2016)

Crowding modulates the conformation, affinity, and activity of the components of the bacterial disaggregase machinery

G. Celaya, J. A. Fernandez-Higuero, I. Martin, G. Rivas, F. Moro and A. Muga

J Mol Biol. 428, 2474-2487 (2016)

Triatomines intrahaemocoelic inoculation protocol: a useful tool to check infectivity in insects

G.S. Rozas-Denis, G.A. Marti, N.L. Cifuentes, F. Guhl and D.M.A. Guérin

J. Biol. Methods 3(2), e40. DOI: 10.4440/jbm.216.46 (2016)

The use of two-photon FRET-FLIM to study protein interactions during nuclear envelope fusion in vivo and in vitro

R.D. Byrne, B. Larijani and D.L. Poccia

Methods Mol Biol. 1411, 123-132 (2016)

Reflections on soil contamination research from a biologist\\\'s point of view

M.T. Gomez-Sagasti, L. Epelde, I. Alkorta and C. Garbisu

Applied Soil Ecology. 105, 207-210 (2016)

Synthetic biology as a challenge to understand the autonomy of the living

S. Murillo-Sanchez and K. Ruiz-Mirazo

Isegoría 55, 551-575 (2016)

Fatty acids double role in the prebiotic formation of a hydrophobic dipeptide

S. Murillo-Sánchez, D. Beaufils, J. M. González Mañas, R. Pascal and K. Ruiz-Mirazo

Chem. Sci. 7, 3406-3413 (2016)

Reflections on the origin of life. More than an \\\'evolutionary\\\' problem

K. Ruiz-Mirazo and A. Moreno

Mètode SSJ. 6, 151-159 (2016)

Cholesterol-ceramide interactions in phospholipid and sphingolipid bilayers as observed by positron annihilation lifetime spectroscopy and molecular dynamics simulations

A.B. García Arribas, R. Axpe, J.I. Mujika, D. Mérida, J.V. Busto, J. Sot, A. Alonso, X. Lopez, J.A. García, J.M. Ugalde, F. Plazaola and F.M. Goñi

Langmuir. 32, 5434-5444 (2016)

A small molecule inhibitor of PDK1/PLCγ1 interaction blocks breast and melanoma cancer cell invasion

C. Raimondi, V. Calleja, R. Ferro, A. Fantin, A.M. Riley, B.V. Potter, C.H. Brenan, T. Maffucci, B. Larijani and M. Falasca

Sci Rep. 6, 26142 doi.10.1038/srep26142 (2016)

Thermotropic properties of ceramides in aqueous or lipidic environments

A. Alonso and F.M. Goñi

Book article CRC Press, Boca Raton, FL, USA, pp. 137-151 (2016)

The p.Leu167del mutation in APOE gene causes autosomal dominant hypercholesterolemia by down-regulation of LDL receptor expression in hepatocytes

A. Cenarro, A. Etxebarria, I. De Castro-Oros, M. Stef, A.M. Bea, L. Palacios, R. Mateo-Gallego, A. Benito-Vicente, H. Ostolaza, T. Tejedor, C. Martin and F. Civeira

J Clin Endocrinol Metab. 101, 2113-2121 (2016)

Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA

D. Albesa-Jové, Z. Svetlíková, M. Tersa, E. Sancho-Vaello, A. Carreras-González, P. Bonnet, P. Arrasate, A. Eguskiza, S.K. Angala, J.O. Cifuente, J. Korduláková, M. Jackson, K. Mikušová and M.E. Guerin

Nat Commun. 11, 10906. doi: 10.1038/ncomms10906 (2016)

PTEN recruitment controls synaptic and cognitive function in Alzheimer\\\\\\\'s models

S. Knafo, C. Sanchez-Puelles, E. Palomer, I. Delgado, J.E. Draffin, J. Mingo, T. Wahle, K. Kaleka, L. Mou, I. Pereda-Perez, E. Klosi, E.B. Faber, H.M. Chapman, L. Lozano-Montes, A. Ortega-Molina, L. Ordóñez-Gutiérrez, F. Wandosell, J. Viña, C.G. Dotti, R.A. Hall, R. Pulido, N.Z. Gerges, A.M Chan, M.R. Spaller, M. Serrano, C. Venero and J.A. Esteban

Nat Neurosci. 19(3):443-53. doi: 10.1038/nn.4225 (2016)

Correction: HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer

M. Gijsen, P. King, T. Perera, P.J. Parker, A.L. Harris, B. Larijani and A. Kong

PLoS Biol. 7, e1002414. doi: 10.1371/journal.pbio.1002414 (2016)

Approaches to polyunsaturated sphingolipids: new conformationally restrained analogs with minimal structural modifications

I. Nieves, J.L. Abad, L.R. Montes, F.M. Goñi and A. Delgado

Tetrahedron 72, 237-265 (2016)