| Biofisika

Access all the 2010-2011-2012 publications through the next link.

Public 2010-2012

Access all the publications since 2013 on (included) through the next links.

αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors.

I. Devesa, C. Ferrándiz-Huertas, S. Mathivanan, C. Wolf, R. Luján, J.P. Changeux and A. Ferrer-Montiel.

Proc Natl Acad Sci USA. 111, 18345-18350 (2014).

High-melting lipid mixtures and the origin of detergent-resistant membranes studied with temperature-solubilization diagrams.

J. Sot, M.M. Manni, A.R. Viguera, V. Castañeda, A. Cano, C. Alonso, D. Gil, M. Valle, A. Alonso and F.M. Goñi.

Biophys J. 107, 2828-2837 (2014).

Biophysical properties of novel 1-deoxy-(dihydro)ceramides occurring in mammalian cells.

N. Jiménez-Rojo, J. Sot, J.V. Busto, W.A. Shaw, J. Duan, A.H. Merrill, Jr., A. Alonso and F.M. Goñi.

Biophys. J. 107, 2850-2859 (2014).

Calorimetric markers of Bence Jones and nonsecretory multiple myeloma serum proteome.

S. Todinova, S. Krumova, R. Radoeva, L. Gartcheva and S. G. Taneva.

Anal Chem. 86, 12355-12361 (2014).

Advantages and versatility of fluorescence-based methodology to characterize the functionality of LDLR and class mutation assignment

A. Etxebarria, A. Benito-Vicente, A.C. Alves, H. Ostolaza, M. Bourbon and C. Martin

. PLoS One. 9(11):e112677. doi: 10.1371/journal.pone.0112677 (2014).

Cholesterol-dependent membrane fusion induced by the gp41 membrane-proximal external region-transmembrane domain connection suggests a mechanism for broad HIV-1 neutralization.

B. Apellániz, E. Rujas, P. Carravilla, J. Requejo-Isidro, N. Huarte, C. Domene and J.L. Nieva.

J Virol. 88, 13367-13377 (2014).

Stochastic transport through carbon nanotubes in lipid bilayers and live cell membranes.

J. Geng, K. Kim, J. Zhang, A. Escalada, R. Tunuguntla, L.R. Comolli, F.I. Allen, A.V. Shnyrova, K.R. Cho, D. Muñoz, Y.M. Wang, C. P. Grigoropoulos, C.M. Ajo-Franklin, V.A. Frolov and A. Noy.

Nature 514, 612-615 (2014).

Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity.

M. Orzáez, M. Sancho, S. Marchán, L. Mondragón, R. Montava, J.G. Valero, O. Landeta, G. Basañez, R.J. Carbajo, A. Pineda-Lucena, J. Bujons, A. Moure, A. Messeguer, C. Lagunas, C. Herrero and E. Pérez-Payá.

PLoS One. 9(10):e110979. doi: 10.1371/journal.pone.0110979. (2014).

Lipid-dependent bimodal MCL1 membrane activity.

O. Landeta, J.G. Valero, H. Flores-Romero, I. Bustillo-Zabalbeitia, A. Landajuela, M. García-Porras, O. Terrones and G. Basañez.

ACS Chem Biol. 9, 2852-2863 (2014).

On the dynamics of the adenylate energy system: homeorhesis vs homeostasis.

I.M. De la Fuente, J.M. Cortés, E. Valero, M. Desroches, S. Rodrigues and L. Martínez.

PLoS One 9(10): e108676. doi:10.1371/journal.pone.0108676 (2014).

Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding.

M.A. Bonache, A. Alaimo, C. Malo, O. Millet, A. Villarroel and R. González-Muñiz.

Org Biomol Chem. 12, 8877-8887 (2014).

The phosphatidyl-myo-Inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo.

F. Boldrin, M. Ventura, G. Degiacomi, S. Ravishankar, C. Sala, Z. Svetlikova, A. Ambady, N. Dhar, J. Kordulakova, M. Zhang, A. Serafini, V.G. Vishwas, G.S. Kolly, N. Kumar, G. Palù, M. Guerin, K. Mikusova, S.T. Cole and R. Manganelli.

J Bacteriol. 196, 3441-3451 (2014).

Conservation of proteo-lipid nuclear membrane fusion machinery during early embryogenesis.

R.D. Byrne, S. Veeriah, C.J. Applebee, B. Larijani.

Nucleus. 5, 441-448 (2014).

Ether-versus ester-linked phospholipid bilayers containing either linear or branched apolar chains.

D. Balleza, A.B. Garcia-Arribas, J. Sot, K. Ruiz-Mirazo and F.M. Goñi.

Biophys J. 107, 1364-1374 (2014).

A cholesterol recognition motif in human phospholipid Scramblase 1.

I.M.D. Posada, J. Fantini, F.X. Contreras, F. Barrantes, A. Alonso and F.M. Goñi.

Biophys J. 107, 1383-1392 (2014).

High-throughput time-resolved FRET reveals Akt/PKB activation as a poor prognostic marker in breast cancer.

S. Veeriah, P. Leboucher, J. de Naurois, N. Jethwa, E. Nye, T. Bunting, R. Stone, G. Stamp, V. Calleja, S.S. Jeffrey, P. Parker and B. Larijani.

Cancer Res. 74, 4983-4995 (2014).

The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation.

F.J. Taberner, A. López-Córdoba, G. Fernández-Ballester, Y. Korchev and A. Ferrer-Montiel.

J Biol Chem. 289, 28579-28594 (2014).

Principle of duality in phospholipids: regulators of membrane morphology and dynamics.

B. Larijani, F. Hamati, A. Kundu, G.C. Chung, M.C. Domart , L. Collinson and D.L. Poccia.

Biochem Soc Trans. 42, 1335-1342 (2014).

Acute regulation of PDK1 by a complex interplay of molecular switches.

V. Calleja, M. Laguerre, G. de Las Heras-Martinez, P.J. Parker, J. Requejo-Isidro and B. Larijani.

Biochem Soc Trans. 42, 1435-1440 (2014).

Correlative and integrated light and electron microscopy of in-resin GFP fluorescence, used to localise diacylglycerol in mammalian cells.

C.J. Peddie, K. Blight, E. Wilson, C. Melia, J. Marrison, R. Carzaniga, M.C. Domart, P. O\'Toole, B. Larijani and L.M. Collinson.

Ultramicroscopy,143, 3-14 (2014).

Sphingosine induces the aggregation of imine-containing peroxidized vesicles.

N. Jiménez-Rojo, A.R. Viguera, M.I. Collado, K.H. Sims, C. Constance, K. Hill, W.A. Shaw, F.M. Goñi and A. Alonso.

Biochim. Biophys. Acta 1838, 2071-2077 (2014).

The ever changing moods of calmodulin: how structural plasticity entails transductional adaptability.

A. Villarroel, M. Taglialatela, G. Bernardo-Seisdedos, A. Alaimo, J. Agirre, A. Alberdi, C. Gomis-Pérez, M.V. Soldovieri, P. Ambrosino, C. Malo and P. Areso.

J Mol Biol. 426, 2717-2735 (2014).

Specific interaction with cardiolipin triggers functional activation of Dynamin-Related Protein 1.

I. Bustillo-Zabalbeitia, S. Montessuit, E. Raemy, G. Basañez, O. Terrones and J.C. Martinou.

PLoS One. 9:e102738 (2014).

HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1.

Nuria Izquierdo-Useros, Maier Lorizate, Paul J. McLaren, Amalio Telenti, Hans-Georg Krausslich, Javier Martinez-Picado ,

PLoS Pathog. 10:e1004146 (2014).

Structural basis of chitin oligosaccharide deacetylation.

E. Andrés, D. Albesa-Jové, X. Biarnés, B.M. Moerschbacher, M. E. Guerin and A. Planas.

Angew Chem Int Ed Engl. 53, 1-6 (2014).

N-Nervonoylsphingomyelin (C24:1) prevents lateral heterogeneity in cholesterol-containing membranes.

S. Maté, J.V. Busto, A. García-Arribas, J. Sot, R. Vázquez, V. Herlax, C. Wolf, L. Bakás and F.M. Goñi.

Biophys. J. 106 2606–2616 (2014).

Membrane permeabilization induced by sphingosine: effect of negatively charged lipids.

N. Jiménez-Rojo, J. Sot, A.R. Viguera, M.I. Collado, A. Torrecillas, J.C. Gómez-Fernández, F.M. Goñi and A. Alonso.

Biophys. J. 106 2577–2584 (2014).

Suppression and enhancement of transcriptional noise by DNA looping

J.M. Vilar and L. Saiz.

Phys Rev E Stat Nonlin Soft Matter Phys. 89:062703 (2014).

Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer\'s disease.

M. Torres, S.L. Price, M.A. Fiol-deRoque, A. Marcilla-Etxenike, H. Ahyayauch, G. Barceló-Coblijn, S. Terés, L. Katsouri, M. Ordinas, D.J. López, M. Ibarguren, F.M. Goñi, X. Busquets, J. Vitorica, M. Sastre and P.V. Escribá.

Biochim. Biophys. Acta 1838, 1680-1692 (2014).

Structure of the atypical bacteriocin pectocin M2 implies a novel mechanism of protein uptake.

R. Grinter, I. Josts, K. Zeth, A.W. Roszak, L.C. McCaughey, R.J. Cogdell, J.J. Milner, S.M. Kelly, O. Byron and D. Walker.

Mol. Microbiol. 93, 234-246 (2014).

The three lives of viral fusion peptides

B. Apellániz, N. Huarte, E. Largo and J.L. Nieva.

Chem Phys Lipids. 181, 40-55 (2014).

Structure of BamA, an essential factor in outer membrane protein biogenesis.

R. Albrecht, M. Schütz, P. Oberhettinger, M. Faulstich, I. Bermejo, T. Rudel, K. Diederichs and K. Zeth.

Acta Crystallogr D Biol Crystallogr. 70, 1779-1789 (2014).

Axial helix rotation as a mechanism for signal regulation inferred from the crystallographic analysis of the E. coli serine chemoreceptor.

H.U. Ferris, K. Zeth, M. Hulko, S. Dunin-Horkawicz and A.N. Lupas.

J Struct Biol. 186, 349-56 (2014).

The basic structure and dynamics of cell membranes: An update of the Singer-Nicolson model.

F.M. Goñi.

Biochim. Biophys. Acta 1838, 1467-1476 (2014).

Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.

D. Albesa-Jové, L.R. Chiarelli, V. Makarov, M.R. Pasca, S. Urresti, G. Mori, E. Salina, A. Vocat, N. Comino, E. Mohorko, S. Ryabova, B. Pfieiffer, A.L. Lopes Ribeiro, A. Rodrigo-Unzueta, M. Tersa, G. Zanoni, S. Buroni, K.H. Altmann, R.C. Hartkoorn, R. Glockshuber, S.T. Cole, G. Riccardi and M.E. Guerin.

ACS Chem Biol. 9, 1567-1575 (2014).

Biophysical properties of sphingosine, ceramides and other simple sphingolipids.

F.M. Goñi, J. Sot and A. Alonso.

Biochem Soc Trans. 42, 1401-1408 (2014).

Entropy of leukemia on multidimensional morphological and molecular landscapes.

J. M. G. Vilar.

Phys. Rev. X 4, 021038 (2014).

Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology

A. Oliveras, M. Roura-Ferrer, L. Solé, A. de la Cruz, A. Prieto, A. Etxebarria, J. Manils, D. Morales-Cano, E. Condom, C. Soler, A. Cogolludo, C. Valenzuela, A. Villarroel, N. Comes and A. Felipe.

Arterioscler Thromb Vasc Biol. 34, 1522-1530 (2014).

Crowding activates ClpB and enhances its association with DnaK for efficient protein aggregate reactivation

I. Martín, G. Celaya, C. Alfonso, F. Moro, G. Rivas and A. Muga.

Biophys J. 106, 2017-2027 (2014).

Effect of specific amino acid substitutions in the putative fusion peptide of structural glycoprotein E2 on classical swine fever virus replication.

I.J. Fernández-Sainz, E. Largo, D.P. Gladue, P. Fletcher, V. O\'Donnell, L.G. Holinka, L.B. Carey, X. Lu, J.L. Nieva and M.V. Borca.

Virology. 456, 121-130 (2014).

Alcoholism: common and oxidative damage biomarkers.

S. Muñiz-Hernández, J.B Velázquez-Fernández, J. Díaz-Chávez, R.C López-Sánchez, J.A Hernández and A. Rendón-Ramírez.

J Clin Toxicol doi: 10.4172/2161-0495. S7-006 (2014).

Membrane binding of human phospholipid scramblase 1 cytoplasmic domain.

I.M. Posada, L. Sánchez-Magraner, J.H. Hervás, A. Alonso, H.L. Monaco and F.M. Goñi.

Biochim. Biophys. Acta 1838, 1785-1792 (2014).

Human LDL structural diversity studied by IR spectroscopy.

J.A. Fernández-Higuero, A.M. Salvador, C. Martín, J.C. Milicua and J.L. Arrondo.

PLoS One 9, e92426 (2014).

Changes in membrane organization upon spontaneous insertion of 2-hydroxylated unsaturated fatty acids in the lipid bilayer.

A. Khmelinskaia, M. Ibarguren, R.F.M. de Almeida, D.J. López, V.A. Paixa, H. Ahyayauch, F.M. Goñi and P.V. Escribá.

Langmuir 30, 2117-2128 (2014).

Histones and DNA compete for binding polyphosphoinositides in bilayers.

M.G. Lete, J. Sot, H. Ahyayauch, N. Fernández-Rivero, A. Prado, F.M. Goñi and A. Alonso.

Biophys. J. 106, 1092–1100 (2014).

Modelling lipid competition dynamics in heterogeneous protocell populations.

B. Shirt-Ediss, K. Ruiz-Mirazo, F. Mavelli and R.V. Solé.

Sci Rep. 4:5675 doi: 10.1038/srep05675 (2014).

Adaptive long-term monitoring of soil health in metal phytostabilization: ecological attributes and ecosystem services based on soil microbial parameters.

L. Epelde, J.M. Becerril, I. Alkorta and C. Garbisu.

Int J Phytoremediation. 16, 971-981 (2014).

Lamellar gel (Lβ) phases of ternary lipid composition containing ceramide and cholesterol.

J.V. Busto, A.B. García-Arribas, J. Sot, A. Torrecillas, J.C. Gómez-Fernández, F.M. Goñi and A. Alonso.

Biophys. J. 106, 621-630 (2014).

The C-terminal transmembrane domain of human phospholipid scramblase 1 is essential for the protein flip-flop activity and Ca2+-binding.

L. Sánchez-Magraner, I.M. Posada, N. Andraka, F.X. Contreras, A.R. Viguera, D.M. Guérin, J.L.R. Arrondo, H.L. Monaco and F.M. Goñi.

J Membr Biol. 247, 155-165 (2014).

Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10.

A. Kryshtafovych, J. Moult, P. Bales, J.F. Bazan, M. Biasini, A. Burgin, C. Chen, F.V. Cochran, T.K. Craig, R. Das, D. Fass, C. Garcia-Doval, O. Herzberg, D. Lorimer, H. Luecke, X. Ma, D.C. Nelson, M.J. van Raaij, F. Rohwer, A. Segall, V. Seguritan, K. Zeth and T. Schwede.

Proteins 82 Suppl 2, 26-42 (2014).

Pivoting between calmodulin lobes triggered by calcium in the Kv7.2/calmodulin complex.

A. Alaimo, A. Alberdi, C. Gomis-Pérez, J. Fernández-Orth, G. Bernardo-Seisdedos, C. Malo, O. Millet, P. Areso and Á. Villarroel.

PLoS One, Volume 9 | Issue 1 | e86711 (2014).

Structure-function relationships of membrane-associated GT-B glycosyltransferases.

D. Albesa-Jové, D. Giganti, M. Jackson, P.M. Alzari PM, and M.E. Guerin.

Glycobiology, 24, 108-124 (2014).

Single-molecule site-specific detection of protein phosphorylation with a nanopore

Rosen CB, Rodriguez-Larrea D, Bayley H.

Nature Biotechnology. 2014 Feb;32(2):179-81

Structure and immunogenicity of a peptide vaccine, including the complete HIV-1 gp41 2F5 epitope: implications for antibody recognition mechanism and immunogen design.

S. Serrano, A. Araujo, B. Apellániz, S. Bryson, P. Carravilla, I. de la Arada, N. Huarte, E. Rujas, E.F. Pai, J.L.R. Arrondo, C. Domene, M.A. Jiménez and J.L. Nieva.

J Biol Chem. 289, 6565-6580 (2014).

Lipid bilayers containing sphingomyelins and ceramides of varying N-acyl lengths: A glimpse into sphingolipid complexity.

N. Jiménez-Rojo, A.B. García-Arribas, J. Sot, A. Alonso and F.M. Goñi.

Biochim. Biophys. Acta 1838, 456–464 (2014).