Structural biology of virus-host interactions
Group leader
Juan Fontana
Email
Phone
+34 946 01 8053
Address
Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)
Research goal
We use cryo-electron microscopy, combined with other structural and molecular biology approaches, to characterise macromolecular assemblies and viruses that are a current public health risk, like influenza, herpesviruses and bunyaviruses and their interactions with the host cell.
Group members
Juan Fontana
CSIC Scientist
Publications
Debski-Antoniak O, Flynn A, Klebl DP, Rojas Rechy MH, Tiede C, Wilson IA, Muench SP, Tomlinson D, Fontana J
Exploiting the Affimer platform against influenza A virus
mBio. 2024 Aug 14;15(8):e0180424
DOI: 10.1128/mbio.01804-24
Shaw AB, Tse HN, Byford O, Plahe G, Moon-Walker A, Hover SE, Saphire EO, Whelan SPJ, Mankouri J, Fontana J, Barr JN
Cellular endosomal potassium ion flux regulates arenavirus uncoating during virus entry
mBio. 2024 Jul 17;15(7):e0168423
doi: 10.1128/mbio.01684-23
Byford O, Shaw AB, Tse HN, Todd EJAA, Álvarez-Rodríguez B, Hewson R, Fontana J, Barr JN
Lymphocytic choriomeningitis arenavirus requires cellular COPI and AP-4 complexes for efficient virion production
J Virol. 2024 Mar 19;98(3):e0200623
doi: 10.1128/jvi.02006-23
Hover S, Charlton FW, Hellert J, Swanson JJ, Mankouri J, Barr JN, Fontana J
Organisation of the orthobunyavirus tripodal spike and the structural changes induced by low pH and K+ during entry
Nat Commun. 2023 Sep 21;14(1):5885
doi: 10.1038/s41467-023-41205-w
Hopkins FR, Álvarez-Rodríguez B, Heath GR, Panayi K, Hover S, Edwards TA, Barr JN, Fontana J
The Native Orthobunyavirus Ribonucleoprotein Possesses a Helical Architecture
mBio. 2022 Aug 30;13(4):e0140522
doi: 10.1128/mbio.01405-22