Single-Molecule Nanopore Biophysics

Group leader
David Rodriguez-Larrea
Phone
+34 946 01 8002
Address

Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

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Research goal

Our research is focused on understanding protein translocation through membrane pores and on the biotechnological applications of such processes.

Group members
Research Assistant
Research Assistant
University Lecturer
Publications

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Alfaro JA, Bohländer P, Dai M, Filius M, Howard CJ, van Kooten XF, Ohayon S, Pomorski A, Schmid S, Aksimentiev A, Anslyn EV, Bedran G, Cao C, Chinappi M, Coyaud E, Dekker C, Dittmar G, Drachman N, Eelkema R, Goodlett D, Hentz S, Kalathiya U, Kelleher NL, Kelly RT, Kelman Z, Kim SH, Kuster B, Rodriguez-Larrea D, Lindsay S, Maglia G, Marcotte EM, Marino JP, Masselon C, Mayer M, Samaras P, Sarthak K, Sepiashvili L, Stein D, Wanunu M, Wilhelm M, Yin P, Meller A, Joo C.

The emerging landscape of single-molecule protein sequencing technologies.
Nat Methods. 2021 Jun;18(6):604-617.
DOI: 10.1038/s41592-021-01143-1

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Rodriguez-Larrea D.

Single-aminoacid discrimination in proteins with homogeneous nanopore sensors and neural networks.
Biosens Bioelectron. 2021 May 15;180:113108.
DOI: 10.1016/j.bios.2021.113108

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Feng J, Martin-Baniandres P, Booth MJ, Veggiani G, Howarth M, Bayley H, Rodriguez-Larrea D.

Transmembrane protein rotaxanes reveal kinetic traps in the refolding of translocated substrates.
Commun Biol. 2020 Apr 3;3(1):159.
DOI: 10.1038/s42003-020-0840-5

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Rosen CB, Bayley H, Rodriguez-Larrea D.

Free-energy landscapes of membrane co-translocational protein unfolding.
Commun Biol. 2020 Apr 3;3(1):160.
DOI: 10.1038/s42003-020-0841-4

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Rodríguez J, Learte-Aymamí S, Mosquera J, Celaya G, Rodríguez-Larrea D, Vázquez ME, Mascareñas JL.

DNA-binding miniproteins based on zinc fingers. Assessment of the interaction using nanopores.
Chem Sci. 2018 Apr 10;9(17):4118-4123.
DOI: 10.1039/c7sc05441f