Cell Membrane Organisation and Dynamics

Group leader
Adai Colom Diego
Phone
+34 946 01 8051
Address

Biofisika Institute (CSIC-UPV/EHU)
Science Park of the UPV/EHU
Barrio Sarriena s/n. 48940 Leioa, Bizkaia (Spain)

Google Maps Get directions

Research goal

We aim to understand the role of membrane mechanics and protein dynamics involved in different cellular processes. In particular, we are focussed on immunological synapse, viral infection and embriogenesis. We use a wide range of systems (u to embryos) and technics, particularly HS-AFM and Fast-FLIM.

Group members
Marie Curie Postdoctoral Fellow
PhD Student
Postdoctoral Fellow
Postdoctoral Fellow
Research Technician
Ramon y Cajal Fellow / Ikerbasque Reseach Fellow
Publications

Read the article

Rodriguez-Lejarraga P, Martin-Iglesias S, Moneo-Corcuera A, Colom A, Redondo-Morata L, Giannotti MI, Petrenko V, Monleón-Guinot I, Mata M, Silvan U, Lanceros-Mendez S.
The surface charge of electroactive materials governs cell behaviour through its effect on protein deposition
Acta Biomater. 2024 Jun 29:S1742-7061(24)00352-0.
doi: 10.1016/j.actbio.2024.06.039

Read the article

Huang Y, Chandran Suja V, Yang M, Malkovskiy AV, Tandon A, Colom A, Qin J, Fuller GG
Interfacial stresses on droplet interface bilayers using two photon fluorescence lifetime imaging microscopy
J Colloid Interface Sci. 2024 Jan;653(Pt B):1196-1204
doi: 10.1016/j.jcis.2023.09.092

Read the article

Franco A, Gracia P, Colom A, Camino JD, Fernández-Higuero JÁ, Orozco N, Dulebo A, Saiz L, Cremades N, Vilar JMG, Prado A, Muga A.

All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species
Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2105548118
DOI: 10.1073/pnas.2105548118

Read the article

Mahecic D, Carlini L, Kleele T, Colom A, Goujon A, Matile S, Roux A, Manley S.

Mitochondrial membrane tension governs fission
Cell Rep. 2021 Apr 13;35(2):108947
DOI: 10.1016/j.celrep.2021.108947

Read the article

Zuttion F, Colom A, Matile S, Farago D, Pompeo F, Kokavecz J, Galinier A, Sturgis J, Casuso I.

High-speed atomic force microscopy highlights new molecular mechanism of daptomycin action.
Nat Commun. 2020 Dec 9;11(1):6312
DOI: 10.1038/s41467-020-19710-z

Read the article

Jiménez-Rojo N, Leonetti MD, Zoni V, Colom A, Feng S, Iyengar NR, Matile S, Roux A, Vanni S, Weissman JS, Riezman H.

Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway.
Curr Biol. 2020 Aug 20:S0960-9822(20)31084-8.  
DOI: 10.1016/j.cub.2020.07.059

Read the article

García-Calvo J, Maillard J, Fureraj I, Strakova K, Colom A, Mercier V, Roux A, Vauthey E, Sakai N, Fürstenberg A, Matile S.

Fluorescent Membrane Tension Probes for Super-Resolution Microscopy: Combining Mechanosensitive Cascade Switching with Dynamic-Covalent Ketone Chemistry.
J Am Chem Soc. 2020 Jul 15;142(28):12034-12038
DOI: 10.1021/jacs.0c04942

Read the article

T. Sansen, D. Sanchez-Fuentes, R. Rathar, A. Colom-Diego, F. El Alaoui, J. Viaud, M. Macchione, S. de Rossi, S. Matile, R. Gaudin, V. Bäcker, A. Carretero-Genevrier*, and L. Picas.

Mapping Cell Membrane Organization and Dynamics Using Soft Nanoimprint Lithography.
ACS Appl Mater Interfaces. 2020 Jul 1;12(26):29000-29012
DOI: 10.1021/acsami.0c05432

Read the article

Goujon A, Colom A, Straková K, Mercier V, Mahecic D, Manley S, Sakai N, Roux A, Matile S.

Mechanosensitive Fluorescent Probes to Image Membrane Tension in Mitochondria, Endoplasmic Reticulum, and Lysosomes.
J Am Chem Soc. 2019 Feb 27;141(8):3380-3384
DOI: 10.1021/jacs.8b13189

Read the article

Riggi M, Niewola-Staszkowska K, Chiaruttini N, Colom A, Kusmider B, Mercier V, Soleimanpour S, Stahl M, Matile S, Roux A, Loewith R.

Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2.
Nat Cell Biol. 2018 Sep;20(9):1043-1051
DOI: 10.1038/s41556-018-0150-z

Read the article

Colom A, Derivery E, Soleimanpour S, Tomba C, Molin MD, Sakai N, González-Gaitán M, Matile S, Roux A.

A fluorescent membrane tension probe.
Nat Chem. 2018 Nov;10(11):1118-1125
DOI: 10.1038/s41557-018-0127-3