New Titan Krios Cryo-EM at the FBB-IBF

Next 28th of September we will be installing a Thermofisher Krios G4 Cryo-EM, one of the most advanced Cryo EMs in the world. We have carried out extensive renovation work at the FBB-IBF premises to facilitate the installation of the Titan Krios. It will be accessible to all research groups both public and private, national and international, and will foster the advancement of the Basque Country in biosciences and biomedicine.

Cryo-electron microscopy (cryo-EM) allows the visualisation and determination, to atomic resolution in some cases, of the structure of biological specimens (proteins, nucleic acids, macromolecular complexes, organelles, cells and tissues) in a physiological environment using specialised electron cryo-microscopes. Spectacular advances in technology and software over the last decade have propelled cryo-EM to launch a global revolution in structural biology, where the number of structures solved by cryo-EM is rapidly increasing at a quasi-exponential rate. Furthermore, due to the advantages of cryo-EM for studying large and complex cellular systems of biological and biomedical interest related to health and disease, most of these investigations have been published in high-impact journals. Consequently, high resolution cryo-EM has been incorporated into the drug discovery and development programmes of large pharmaceutical companies.