Nerea Huarte

Associate Lecturer (UPV/EHU)

She earned her BS in Biochemistry in 2005 and MS in Biochemistry and Molecular Biology in 2007 in the Science and Technology School from the University of the Basque Country and the PhD in Science (Biophysics) in 2008 in the University of the Basque Country. She did postdoctoral research at the Biophysics Unit (CSIC, UPV/EHU) working on the study of the lipidic component of enveloped viruses as HIV. Her research has been focused on this topic since then.

Publications

Structure-Related Roles for the Conservation of the HIV-1 Fusion Peptide Sequence Revealed by Nuclear Magnetic Resonance

S. Serrano, N. Huarte, E. Rujas, D. Andreu, J.L. Nieva and M.A. Jimenez

Biochemistry 56, 5503-5511 doi: 10.1021/acs.biochem.7b00745 (2017)
Effects of HIV-1 gp41-Derived Virucidal Peptides on Virus-like Lipid Membranes

P. Carravilla, A. Cruz, I. Martin-Ugarte, I.R. Oar-Arteta, J. Torralba, B. Apellaniz, J. Perez-Gil, J. Requejo-Isidro, N. Huarte and J.L. Nieva

Biophys J 113, 1301-1310 doi: 10.1016/j.bpj.2017.06.061 (2017)
Envelope glycoprotein mobility on HIV-1 particles depends on the virus maturation state

J. Chojnacki, D. Waithe, P. Carravilla, N. Huarte, S. Galiani, J. Enderlein and C. Eggeling

Nat Commun 8, 545 doi: 10.1038/s41467-017-00515-6 (2017)
Functional organizacion of the HIV lipid envelope

N. Huarte, P. Carravilla, A. Cruz, M. Lorizate, J.A. Nieto-Garai, H.G. Kräusslich, J. Perez-Gil, J.M. Requejo and J.L. Nieva

Sci Rep 6 34190. doi: 10.1038/srep34190 (2016)
End-product diacylglycerol enhances the activity of PI-PLC through changes in membrane domain structure

Ahyayauch H, Sot J, Collado MI, Huarte N, Requejo-Isidro J, Alonso A, Goni FM

Biophys J. 108:1672-82 (2015)
Two-Photon Laurdan Studies of the Ternary Lipid Mixture DOPC:SM:Cholesterol Reveal a Single Liquid Phase at Sphingomyelin:Cholesterol Ratios Lower Than 1

P. Carravilla, J.L. Nieva, F.M. Goñi, J. Requejo-Isidro and N. Huarte

Langmuir. 31(9):2808-17 (2015)
Cholesterol-dependent membrane fusion induced by the gp41 membrane-proximal external region-transmembrane domain connection suggests a mechanism for broad HIV-1 neutralization.

B. Apellániz, E. Rujas, P. Carravilla, J. Requejo-Isidro, N. Huarte, C. Domene and J.L. Nieva.

J Virol. 88, 13367-13377 (2014).
The three lives of viral fusion peptides

B. Apellániz, N. Huarte, E. Largo and J.L. Nieva.

Chem Phys Lipids. 181, 40-55 (2014).
Structure and immunogenicity of a peptide vaccine, including the complete HIV-1 gp41 2F5 epitope: implications for antibody recognition mechanism and immunogen design.

S. Serrano, A. Araujo, B. Apellániz, S. Bryson, P. Carravilla, I. de la Arada, N. Huarte, E. Rujas, E.F. Pai, J.L.R. Arrondo, C. Domene, M.A. Jiménez and J.L. Nieva.

J Biol Chem. 289, 6565-6580 (2014).
Pore-forming activity of pestivirus p7 in a minimal model system supports genus-specific viroporin function.

E. Largo, D.P. Gladue, N. Huarte, M.V. Borca and J.L. Nieva.

Antiviral Res. 101, 30-36 (2014).
Recognition of membrane-bound fusion-peptide/MPER complexes by the HIV-1 neutralizing 2F5 antibody: implications for Anti-2F5 immunogenicity.

N. Huarte, A. Araujo, R. Arranz, M. Lorizate, H. Quendler, R. Kunert, J.M. Valpuesta and J.L. Nieva.

PLoS One, 7, e52740. doi: 10.1371 (2012).