Virus Research and Development

Virus Research and Development

Learning about the structure of macromolecules of biological interest (enzymes, receptors, large molecular aggregates such as viruses) enables the mechanisms of the biochemical functions they perform to be interpreted. Protein crystallography, currently the most advanced and powerful technique for determining atomic structures, is used by our group to study a wide range of macromolecules. We are currently working on the resolution of the structure of several proteins of interest (membrane protein Scramblase and the eukaryotic toxin FraC) and we are collaborating with national and international centres on other structural projects (Triatoma virus, Potassium Channel KcsA and Acyl-CoA binding protein, among others). In parallel with this crystallography work, we are developing new experimental devices and procedures to enhance protein crystallization.

Along with the basic research described before, our group initiated new research lines associated to the development of biomolecular tools based on Dicistroviruses. These lines comprise the production of natural biopesticides against insect pests, the creation of new molecular tools to enhance the production of recombinant proteins, and the develop of a VLP-based platform for rational design of vaccines.

 

Team

Senior Researchers

Collaborators

Relevant Publications



Seroprevalence of Triatoma virus (Dicistroviridae:Cripaviridae) antibodies in Chagas disease patients

J.F.B. Querido, M.G. Echeverría, G.A. Marti, R.Medina Costa, M.L. Susevich, J.E. Rabinovich, A. Copa, N.A. Montaño, L. Garcia, M. Cordova, F. Torrico, R. Sánchez-Eugenia, L. Sánchez-Magraner, X. Muñiz-Trabudua, I. López-Marijuan, G. S. Rozas-Dennis, P. Diosque, A. M. De Castro, C. Robello, J. S. Rodríguez, J. Altcheh, P. M. Salazar-Schettino, M. I. Bucio Torres, B. Espinoza, D. M. A. Guérin, and M. Sousa Silva

Parasites & Vectors Jan 17;8(1):29 (2015)



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