The R&D programs of BIOFISIKA are grouped in two main Research Lines and five Research Sublines. This rational combination of independent group abilities and skills in supplementary fields contributes to reduce scientific dispersion and undertake more ambitious and complex research projects. The distribution of the research groups in the different Research Lines respond to the will of BIOFISIKA to create a unique Research and Training program able to exploit all the singularities present in the Center, fostering the complementarities and synergies of the different groups.
Click the boxes below to go through the different Research Lines for each program
BIOFISIKA Research line organisation
Single-molecule Biophysics
We explore the behaviour of single-protein molecules as they are forced to translocate through nanometer-size pores inserted in lipid membranes. Measuring the ionic current through the pore, we are able to follow their unfolding and refolding pathways. Such pathways are vectorial, as those ...
Structure, Function and Nucleocytoplasmatic Traffic of Nuclear Proteins
M. Ángeles Urbaneja, Sonia Bañuelos
Nuclear chaperones are involved among other functions in the chromatin remodeling that take place during various physiological processes such as fertilization (e.g. mediated by nucleoplasmin) and ribosome assembly and cell proliferation control (e.g. mediated by nucleophosmin). Like other ...
Protein Folding and Role of Molecular Chaperones
Adelina Prado, Arturo Muga, Fernando Moro
This research line is focused in nuclear and cytosolic chaperones. Among the cytosolic chaperones we are interested in members of the Hsp60, Hsp70 and Hsp100 families. In particular, we are analyzing the functional cycle of these proteins and how they interact with substrates and modulate ...