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• Synthetic Protocell Biophysics
• Prebiotic Membranes

• Boundary versus enabling conditions for the origins of life: Comment on \\

  Ruiz-Mirazo K.

  Phys Life Rev. 34-35:96-98. (2020) doi: 10.1016/j.plrev.2020.06.001 (2020)

• Definitions of life as epistemic tools that reflect and foster the advance of biological knowledge

  Amilburu, A., Moreno, A. & Ruiz-Mirazo, K.

  Synthese. (2020) doi: 10.1007/s11229-020-02736-7. (2020)

• The Construction of Biological \'Inter-Identity\' as the Outcome of a Complex Process of Protocell Development in Prebiotic Evolution

  Ruiz-Mirazo K, Shirt-Ediss B, Escribano-Cabeza M, Moreno A.

  Front Physiol. 11:530 (2020). doi: 10.3389/fphys.2020.00530 (2020)

• A plea for hypothesis-driven research in prebiotic systems chemistry

  Ruiz-Mirazo K.

  Chem 5 (8), 1920-1922 (2019)

• Soft and dispersed interface-rich aqueous systems that promote and guide chemical reactions

  Serrano-Luginbühl S, Ruiz-Mirazo K, Ostaszewski R, Gallou F, Walde P.

  Nature Reviews Chemistry 2, 306–327. doi: 10.1038/s41570-018-0042-6 (2018)

• Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research

  B. Shirt-Ediss, S. Murillo-Sanchez and K. Ruiz-Mirazo. Beilstein J

  Org Chem 13, 1388-1395 doi: 10.3762/bjoc.13.135 (2017)

• Polyamine-RNA-membrane interactions: From the past to the future in biology

  C. Acosta-Andrade, I. Artetxe, M.G. Lete, B.G. Monasterio, K. Ruiz-Mirazo, F.M. Goni and F. Sanchez-Jimenez

  Colloids Surf B Biointerfaces 155, 173-181 doi: 10.1016/j.colsurfb.2017.04.005 (2017)

• Permeability-driven selection in a semi-empirical protocell model: the roots of prebiotic systems evolution

  G. Piedrafita, P.A. Monnard, F. Mavelli and K. Ruiz-Mirazo

  Sci Rep 7, 3141 doi: 10.1038/s41598-017-02799-6 (2017)

• Chemical roots of biological evolution: the origins of life as a process of development of autonomous functional systems

  K. Ruiz-Mirazo, C. Briones and A. de la Escosura

  Open Biol 7, 170050 doi: 10.1098/rsob.170050 (2017)

• Synthetic biology as a challenge to understand the autonomy of the living

  S. Murillo-Sanchez and K. Ruiz-Mirazo

  Isegoría 55, 551-575 (2016)

• Fatty acids double role in the prebiotic formation of a hydrophobic dipeptide

  S. Murillo-Sánchez, D. Beaufils, J. M. González Mañas, R. Pascal and K. Ruiz-Mirazo

  Chem. Sci. 7, 3406-3413 (2016)

• Reflections on the origin of life. More than an \\\'evolutionary\\\' problem

  K. Ruiz-Mirazo and A. Moreno

  Mètode SSJ. 6, 151-159 (2016)

• Biological regulation: controlling the system from within

  L. Bich, M. Mossio, K. Ruiz-Mirazo and A. Moreno

  Biol. Philos. 31, 237–265 (2016)

• Thermally-induced aggregation and fusion of protein-free lipid vesicles

  Ibarguren M, Bomans Ph, Ruiz-Mirazo K, Frederik PM, Alonso A, Goñi FM

  Colloid Surface B. 136:545-52 (2015)

• Emergent chemical behavior in variable-volume protocells

  B. Shirt-Ediss, R.V. Solé and K. Ruiz-Mirazo.

  Life 5, 1-31 (2015).

• Ether-versus ester-linked phospholipid bilayers containing either linear or branched apolar chains.

  D. Balleza, A.B. Garcia-Arribas, J. Sot, K. Ruiz-Mirazo and F.M. Goñi.

  Biophys J. 107, 1364-1374 (2014).

• Modelling lipid competition dynamics in heterogeneous protocell populations.

  B. Shirt-Ediss, K. Ruiz-Mirazo, F. Mavelli and R.V. Solé.

  Sci Rep. 4:5675 doi: 10.1038/srep05675 (2014).

• Prebiotic systems chemistry: new perspectives for the origins of life.

  K. Ruiz-Mirazo, C. Briones and A. de la Escosura.

  Chem Rev. 114, 285-366 (2014)

• Organizational requirements for multicellular autonomy: insights from a comparative case study.

  A. Arnellos, A. Moreno and K. Ruiz-Mirazo.

  Biol. Philos. 29, 851-884 (2014).

• Synthetic biology: Challenging life in order to grasp, use, or extend it.

  K. Ruiz-Mirazo and A. Moreno.

  Biological Theory 8: 376–382 (2013)

• Theoretical conditions for the stationary reproduction of model protocells.

  F. Mavelli and K. Ruiz-Mirazo.

  Integr. Biol. 5, 324-341 (2013).

• Viability conditions for a compartmentalized proto-metabolic system: a semi-empirical approach

  Piedrafita, G., Ruiz-Mirazo, K., Monnard, P.-A., Cornish-Bowden, A. & Montero, F.

  PLoS ONE 7(6): e39480 (2012)

• Model systems of precursor cellular membranes: long-chain alcohols stabilize spontaneously formed oleic acid vesicles.

  A. Rendón, D. Gil Carton, J. Sot, M. García-Pacios, L.R. Montes, M. Valle, J.L.R. Arrondo, F.M. Goñi and K. Ruiz-Mirazo

  Biophys. J. 102, 278–286 (2012).

• Definir vida: un ejercicio constructivo.

  K. Ruiz-Mirazo.

  SEBBM 175, 3-6 (2013).