Role of Lipids in HIV-1 Life Cycle and in the Development of New Antiviral Strategies

Role of Lipids in HIV-1 Life Cycle and in the Development of New Antiviral Strategies

HIV-1 virus is delimited by a lipid envelope in which fusion proteins (env) are embedded. We have recently identified that sialyllactose, a molecule exposed in specific gangliosides highly enriched in the HIV-1 membrane, is essential for viral uptake into mature. mDCs are potent antigen presenting cells that constantly interact with T cells to initiate immune responses. However, HIV-1 has evolved strategies to subvert mDC antiviral activity and promote infection of CD4+ T cells. Our principal research lines are the following (1) In vivo and in vitro studies of the lipid environment of the HIV-1 fusion protein and the role of lipids in the function and activity of this protein. The information gained from these studies will be used to develop new immunogenic formulations able to generate neutralizing responses. (2) Development of nanoliposomal systems able to deliver antiretroviral drugs within the cell in mDCs context. (3) Design and development of lipidomimetic and raftophilic compounds as viral infection inhibitors

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