Membrane-Acting Toxins and Pathogens

Membrane-Acting Toxins and Pathogens

In recent years, our group has been studying the phenomenon of the interaction of a pathogenic toxin, Escherichia coli α-haemolysin, with erythrocytes and model membranes. This is an example of protein that it is initially synthesized as a water-soluble protein, but on coming into contact with a membrane binds to it, behaving from then on as an intrinsic protein. Our efforts are focused on studying the structural requirements of the toxin for this transformation from the soluble to the membrane-bound state to take place, as well as the parameters that may modulate the interaction with the target membrane. Recently, we have broadened the scope of our work to include another member of the RTX family, the adenylate cyclise toxin from Bordetella pertussis.

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