Mechanisms for Virus-Induced Membrane Fusion

Mechanisms for Virus-Induced Membrane Fusion

Our objective is to determine the molecular mechanism by which membrane glycoproteins of some viruses (HIV, Ebola) induce the fusion of the cell and viral membranes. Prediction tools have been developed to detect the domains that are inserted into the target membrane. Specifically, we seek to understand their behavior as antigenic determinants, and to develop inhibitory agents that would block their destabilizing interaction. A branch of this field consists of the characterization of similar domains that may be involved in the infective power of the prion protein. In parallel, we are studying the mechanism of cell membrane permeabilization, induced by certain viral products (viroporins) during infection.

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