Inter-Domain Relationships in Integral Membrane Proteins

Inter-Domain Relationships in Integral Membrane Proteins

Infections caused by multiple antibiotic resistant pathogenic bacteria have become one of the most important health problems. Bacterial conjugation is the main mechanism responsible for the acquisition of antimicrobial resistance. In particular, the type IV coupling proteins (T4CP) are membrane proteins essential in this process.

Our research aims at inhibiting the spread of antimicrobial resistance among pathogenic bacteria through the disruption of the inter-domain relationships of T4CPs as alternative strategies to conventional antibiotics.

Team

Senior Researchers

Collaborators

  • External Collaborations

    • Professor Elisabeth Grohmann, Professor of Microbiology at the Albert-Ludwigs-University Freiburg, Germany
    • Professor Aurora Martinez, Research Group Biorecognition, Department of Biochemistry and Molecular Biology, University of Bergen, Norway
    • Dr Isabel de Moraes, coordinator and group leader of The Membrane Protein Laboratory (MPL) at Diamond Light Source, Diamond Light Source Ltd, Harwell Science & Innovation Campus Didcot, Oxfordshire

Relevant Publications




View complete list